Medication·Interactions & depletion·Reviewed June 9, 2026
Rifampin interactions.
Rifampin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin D, Vitamin K, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Rifampin at a glance.
A quick, data-grounded summary. The full tables are below.
Rifampin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin D, Vitamin K, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with rifampin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Curcumin Phytosome | Caution | Rifampin can lower exposure to orally administered curcumin, while curcumin may inhibit some enzymes and transporters; the net effect is reduced and... |
| Milk Thistle | Caution | Rifampin is hepatotoxic and silymarin from milk thistle is often taken for liver support; combining them can obscure or complicate interpretation of... |
| St. John's Wort | Caution | St. John's Wort and rifampin are both strong induction concerns for drug-metabolizing enzymes and transporters; the main danger is failure of other... |
| Vitamin D3 | Caution | Rifampin can accelerate vitamin D catabolism during prolonged therapy and may contribute to low vitamin D or bone risk. |
| Vitamin K1 | Caution | Rifampin can alter vitamin K dependent anticoagulation control and prolonged antibiotic therapy may affect vitamin K status. |
What rifampin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin D | Moderate | Rifampin induces hepatic enzymes that accelerate vitamin D catabolism during prolonged therapy. | Vitamin D3 | 25-hydroxyvitamin D |
| Vitamin K | Mild | By inducing hepatic cytochrome P450 enzymes, rifampin accelerates the metabolism and clearance of vitamin K, which can reduce vitamin K-dependent... | Vitamin K1 (phylloquinone) | Prothrombin time / INR |
| Calcium | Mild | Rifampin lowers active vitamin D metabolites through PXR-mediated CYP induction, which secondarily reduces intestinal calcium absorption. Chronic... | Calcium citrate | Serum calcium and serum 25-hydroxyvitamin D |
The full rifampin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common rifampin questions.
Quick answers drawn from the tables above.
What interacts with Rifampin?
In the NutriStack database, Rifampin has 5 documented interactions. The most notable include Curcumin Phytosome, Milk Thistle, St. John's Wort, Vitamin D3, and Vitamin K1. Check any specific combination before taking it and confirm with your prescriber.
Does Rifampin deplete any nutrients?
Rifampin is associated with lowering Vitamin D, Vitamin K, and Calcium with prolonged use. Useful biomarkers to monitor include 25-hydroxyvitamin D, Prothrombin time / INR, and Serum calcium and serum 25-hydroxyvitamin D. Ask your prescriber before adding any replacement supplement.
Is it safe to take Curcumin Phytosome with Rifampin?
NutriStack classifies the Curcumin Phytosome and Rifampin pairing as caution: Rifampin can lower exposure to orally administered curcumin, while curcumin may inhibit some enzymes and transporters; the net effect is reduced and unpredictable... Do not rely on curcumin supplements to produce consistent effects during rifampin therapy, as its already-low bioavailability may be further... Always confirm with your prescriber.
Check your whole stack
See how rifampin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.