Medication·Interactions & depletion·Reviewed June 9, 2026
Rosuvastatin interactions.
Rosuvastatin has 6 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Rosuvastatin at a glance.
A quick, data-grounded summary. The full tables are below.
Rosuvastatin has 6 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with rosuvastatin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Green Tea Extract | Conflict | Repeated green tea extract significantly reduced systemic rosuvastatin exposure in healthy volunteers. This could reduce or unpredictably alter... details → |
| St. John's Wort | Conflict | St. John's Wort induces CYP3A4 and P-glycoprotein, which can reduce rosuvastatin levels. While rosuvastatin is less dependent on CYP3A4 than other... details → |
| Vitamin B3 | Caution | High-dose niacin combined with rosuvastatin increases myopathy risk. Clinical trials have shown that adding niacin to statin therapy does not... details → |
| Coenzyme Q10 | Synergy | Statins inhibit HMG-CoA reductase, which is also upstream of CoQ10 synthesis in the mevalonate pathway. Rosuvastatin can reduce plasma CoQ10 by 40%.... details → |
| Coenzyme Q10 Ubiquinol | Synergy | Rosuvastatin, like all statins, inhibits the mevalonate pathway and reduces endogenous CoQ10 production. This depletion may contribute to... details → |
| Fish Oil | Synergy | Fish oil omega-3 fatty acids can be used with rosuvastatin for residual hypertriglyceridemia. Human pharmacokinetic studies found no clinically... details → |
What rosuvastatin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Coenzyme Q10 Ubiquinol | Plasma CoQ10 |
The full rosuvastatin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common rosuvastatin questions.
Quick answers drawn from the tables above.
What interacts with Rosuvastatin?
In the NutriStack database, Rosuvastatin has 6 documented interactions. The most notable include Green Tea Extract, St. John's Wort, Vitamin B3, Coenzyme Q10, and Coenzyme Q10 Ubiquinol. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Rosuvastatin?
Rosuvastatin is flagged against 2 substances in the database, including Green Tea Extract and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Rosuvastatin deplete any nutrients?
Rosuvastatin is associated with lowering CoQ10 with prolonged use. Useful biomarkers to monitor include Plasma CoQ10. Ask your prescriber before adding any replacement supplement.
Is it safe to take Green Tea Extract with Rosuvastatin?
NutriStack classifies the Green Tea Extract and Rosuvastatin pairing as conflict: Repeated green tea extract significantly reduced systemic rosuvastatin exposure in healthy volunteers. This could reduce or unpredictably alter rosuvastatin's... Avoid starting high-dose green tea extract without checking whether your LDL response remains controlled on rosuvastatin. If you use it, keep the... Always confirm with your prescriber.
Check your whole stack
See how rosuvastatin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.