Medication·Interactions & depletion·Reviewed June 9, 2026
Sucralfate interactions.
Sucralfate has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Sucralfate at a glance.
A quick, data-grounded summary. The full tables are below.
Sucralfate has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with sucralfate.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Timing Sensitive | Calcium supplements can compete for binding and add to the burden of poorly absorbed minerals when taken with sucralfate. |
| Iron | Timing Sensitive | Sucralfate can bind iron in the gut and may reduce iron absorption or the absorption of other oral medications taken with iron. |
| Magnesium Glycinate | Timing Sensitive | Magnesium products may interfere with sucralfate binding behavior and can reduce the predictability of other oral drug absorption. |
| Zinc | Timing Sensitive | Sucralfate can physically bind oral minerals; zinc taken at the same time may have less predictable absorption. |
What sucralfate can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Phosphorus | Moderate | Aluminum in sucralfate can bind intestinal phosphate and reduce absorption, especially with prolonged use or low dietary intake. | Dietary phosphate repletion or clinician-directed phosphate replacement | Serum phosphorus |
The full sucralfate profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common sucralfate questions.
Quick answers drawn from the tables above.
What interacts with Sucralfate?
In the NutriStack database, Sucralfate has 4 documented interactions. The most notable include Calcium, Iron, Magnesium Glycinate, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Does Sucralfate deplete any nutrients?
Sucralfate is associated with lowering Phosphorus with prolonged use. Useful biomarkers to monitor include Serum phosphorus. Ask your prescriber before adding any replacement supplement.
Is it safe to take Calcium with Sucralfate?
NutriStack classifies the Calcium and Sucralfate pairing as timing sensitive: Calcium supplements can compete for binding and add to the burden of poorly absorbed minerals when taken with sucralfate. Take calcium at a different time of day, typically at least 2 hours away from sucralfate. Always confirm with your prescriber.
Check your whole stack
See how sucralfate fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.