Medication·Interactions & depletion·Reviewed June 9, 2026
Tenofovir Disoproxil interactions.
Tenofovir Disoproxil has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus, Phosphate, Vitamin D, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Tenofovir Disoproxil at a glance.
A quick, data-grounded summary. The full tables are below.
Tenofovir Disoproxil has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus, Phosphate, Vitamin D, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with tenofovir disoproxil.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Creatine | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing... |
| Magnesium Glycinate | Caution | Tenofovir disoproxil can cause proximal renal tubular dysfunction (a Fanconi-like syndrome) that produces urinary wasting of phosphate, potassium,... |
| Potassium | Caution | Tenofovir disoproxil-induced proximal renal tubular dysfunction can cause urinary potassium wasting and hypokalemia, sometimes with metabolic... |
| Vitamin C | Caution | Tenofovir disoproxil is eliminated renally and can cause nephrotoxicity, including a Fanconi-like proximal tubulopathy, in susceptible patients.... |
| Calcium | Synergy | Adequate calcium intake is relevant because tenofovir disoproxil can reduce bone mineral density. |
| Vitamin D3 | Synergy | Tenofovir disoproxil can reduce bone mineral density and may contribute to phosphate wasting; correcting vitamin D deficiency is part of bone-risk... |
What tenofovir disoproxil can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Phosphorus | Significant | Tenofovir-associated proximal renal tubulopathy can cause urinary phosphate wasting and hypophosphatemia. | Phosphate replacement only if prescribed | Serum phosphorus, urine protein, urine glucose, renal function |
| Phosphate | Moderate | Tenofovir disoproxil fumarate accumulates in proximal renal tubular cells and impairs mitochondrial function and sodium-phosphate cotransporter... | Phosphate (potassium/sodium phosphate) supplementation under medical supervision if clinically deficient | Serum phosphate, urine phosphate / fractional excretion of phosphate, serum creatinine and eGFR |
| Vitamin D | Mild | Proximal tubular injury reduces renal 1-alpha-hydroxylase activity and impairs conversion of 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D,... | Vitamin D3 (cholecalciferol) | Serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone (PTH) |
| Calcium | Mild | Renal phosphate wasting, reduced active vitamin D, and secondary hyperparathyroidism increase bone turnover and urinary calcium losses; proximal... | Calcium (with vitamin D) supplementation if dietary intake is inadequate | Serum calcium, 24-hour urinary calcium, parathyroid hormone (PTH), bone mineral density (DXA) |
The full tenofovir disoproxil profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common tenofovir disoproxil questions.
Quick answers drawn from the tables above.
What interacts with Tenofovir Disoproxil?
In the NutriStack database, Tenofovir Disoproxil has 6 documented interactions. The most notable include Creatine, Magnesium Glycinate, Potassium, Vitamin C, and Calcium. Check any specific combination before taking it and confirm with your prescriber.
Does Tenofovir Disoproxil deplete any nutrients?
Tenofovir Disoproxil is associated with lowering Phosphorus, Phosphate, Vitamin D, and Calcium with prolonged use. Useful biomarkers to monitor include Serum phosphorus, urine protein, urine glucose, renal function, Serum phosphate, urine phosphate / fractional excretion of phosphate, serum creatinine and eGFR, and Serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone (PTH). Ask your prescriber before adding any replacement supplement.
Is it safe to take Creatine with Tenofovir Disoproxil?
NutriStack classifies the Creatine and Tenofovir Disoproxil pairing as caution: Creatine can raise measured serum creatinine and complicate renal assessment for Tenofovir Disoproxil, which depends on kidney function for dosing or toxicity monitoring. Tell the prescriber about creatine use and avoid creatine loading during acute illness, kidney injury, or therapy requiring close renal dosing. Always confirm with your prescriber.
Check your whole stack
See how tenofovir disoproxil fits your supplements.
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