Medication·Interactions & depletion·Reviewed June 9, 2026
Theophylline interactions.
Theophylline has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Vitamin B6. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Theophylline at a glance.
A quick, data-grounded summary. The full tables are below.
Theophylline has 4 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Vitamin B6. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with theophylline.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Melatonin | Conflict | Theophylline can worsen insomnia and may counter sleep-promoting strategies such as melatonin. |
| St. John's Wort | Conflict | St. John's Wort may induce drug-metabolizing pathways and make theophylline exposure less predictable. |
| Green Tea Extract | Caution | Caffeinated green tea extract can add to methylxanthine stimulation and may worsen tremor, insomnia, tachycardia, nausea, and arrhythmia risk. |
| Vitamin B6 | Synergy | Vitamin B6 may help correct low pyridoxal phosphate status associated with long-term theophylline therapy. |
What theophylline can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin B6 | Moderate | Theophylline exposure has been associated with reduced pyridoxal phosphate status and may increase neurologic vulnerability in susceptible patients. | Vitamin B6 | Plasma pyridoxal-5-phosphate when clinically indicated |
The full theophylline profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common theophylline questions.
Quick answers drawn from the tables above.
What interacts with Theophylline?
In the NutriStack database, Theophylline has 4 documented interactions. The most notable include Melatonin, St. John's Wort, Green Tea Extract, and Vitamin B6. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Theophylline?
Theophylline is flagged against 2 substances in the database, including Melatonin and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Theophylline deplete any nutrients?
Theophylline is associated with lowering Vitamin B6 with prolonged use. Useful biomarkers to monitor include Plasma pyridoxal-5-phosphate when clinically indicated. Ask your prescriber before adding any replacement supplement.
Is it safe to take Melatonin with Theophylline?
NutriStack classifies the Melatonin and Theophylline pairing as conflict: Theophylline can worsen insomnia and may counter sleep-promoting strategies such as melatonin. Address theophylline timing, serum level, and caffeine intake before escalating sleep supplements. Always confirm with your prescriber.
Check your whole stack
See how theophylline fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.