Medication·Interactions & depletion·Reviewed June 9, 2026
Trazodone interactions.
Trazodone has 7 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Trazodone at a glance.
A quick, data-grounded summary. The full tables are below.
Trazodone has 7 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with trazodone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). Combined with 5-HTP, the increased serotonin production creates serotonin... details → |
| L-Tryptophan | Contraindicated | L-Tryptophan is the upstream serotonin precursor. Trazodone is a serotonin reuptake inhibitor and 5-HT2A antagonist with active metabolite mCPP that... details → |
| Alcohol | Caution | Trazodone produces strong sedation through histamine H1 and 5-HT2A blockade. Alcohol is a CNS depressant. Combined use produces marked additive... details → |
| Ashwagandha | Caution | Ashwagandha contains compounds with GABA-A agonist activity that produce mild sedation. Trazodone is a strongly sedating antidepressant. Combined... |
| SAMe | Caution | SAMe has independent serotonergic and antidepressant activity. Combined with trazodone (a serotonin reuptake inhibitor whose active metabolite mCPP... |
| St. John's Wort | Caution | St. John's Wort has SSRI-like activity and induces CYP3A4, which is the primary enzyme that metabolizes trazodone. The combination both adds... details → |
| Valerian Root | Caution | Valerian root acts on GABA-A receptors via valerenic acid, producing sedation. Trazodone is itself a strongly sedating antidepressant commonly used... |
What trazodone can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Sodium | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | – | Serum sodium |
The full trazodone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common trazodone questions.
Quick answers drawn from the tables above.
What interacts with Trazodone?
In the NutriStack database, Trazodone has 7 documented interactions. The most notable include 5-HTP, L-Tryptophan, Alcohol, Ashwagandha, and SAMe. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Trazodone?
Trazodone is flagged against 2 substances in the database, including 5-HTP and L-Tryptophan. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Trazodone deplete any nutrients?
Trazodone is associated with lowering Sodium with prolonged use. Useful biomarkers to monitor include Serum sodium. Ask your prescriber before adding any replacement supplement.
Is it safe to take 5-HTP with Trazodone?
NutriStack classifies the 5-HTP and Trazodone pairing as contraindicated: Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). Combined with 5-HTP, the increased serotonin production creates serotonin syndrome risk. Do NOT take 5-HTP with trazodone. If additional sleep support is needed, discuss non-serotonergic options with your prescriber. Always confirm with your prescriber.
Check your whole stack
See how trazodone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.