Medication·Interactions & depletion·Reviewed June 9, 2026
Valproic Acid interactions.
Valproic Acid has 7 documented interactions in the NutriStack database. Prolonged use is also associated with lower Carnitine, Folate, Vitamin D, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Valproic Acid at a glance.
A quick, data-grounded summary. The full tables are below.
Valproic Acid has 7 documented interactions in the NutriStack database. Prolonged use is also associated with lower Carnitine, Folate, Vitamin D, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with valproic acid.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can add to valproic acid's dizziness, sleepiness, and impaired coordination, and it may increase concern for liver injury. A case-control... details → |
| Lamotrigine | Caution | Valproic acid inhibits the glucuronidation of lamotrigine, approximately doubling lamotrigine levels. This increases the risk of serious skin... details → |
| Calcium | Synergy | Valproic acid has been linked with lower bone mineral density in people with epilepsy, particularly with longer treatment duration. Adequate calcium... details → |
| L-Carnitine | Synergy | L-carnitine is used clinically to address valproic acid-associated carnitine depletion, hyperammonemia, and toxicity risk. Valproic acid can shift... details → |
| Methylfolate | Synergy | Valproic acid has been associated with disturbances in one-carbon metabolism and higher homocysteine in epilepsy studies. Methylfolate may help... details → |
| Vitamin B9 | Synergy | Vitamin B9, usually as folic acid, has human evidence as an adjunct to sodium valproate in acute mania and is also clinically relevant because... details → |
| Vitamin D3 | Synergy | Long-term valproic acid use has been associated with lower 25-hydroxyvitamin D and lower bone mineral density, especially in children and patients... details → |
What valproic acid can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Carnitine | Significant | Valproate increases urinary carnitine loss and forms valproylcarnitine, which can deplete carnitine stores and impair mitochondrial beta-oxidation. | Acetyl-L-Carnitine | Plasma free carnitine |
| Folate | Moderate | Valproate is associated with lower folate status and altered one-carbon metabolism during chronic therapy. | Methylfolate | Serum folate or RBC folate |
| Vitamin D | Moderate | Chronic valproate use is associated with lower vitamin D status and impaired bone health. | Vitamin D3 | 25-OH vitamin D |
| Calcium | Moderate | Long-term valproate therapy is associated with lower bone mineral density and poorer calcium balance. | Calcium | Serum calcium or bone density trend |
| Biotin | Mild | Valproate therapy may lower biotin status in susceptible users. | Vitamin B7 | Clinical assessment |
The full valproic acid profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common valproic acid questions.
Quick answers drawn from the tables above.
What interacts with Valproic Acid?
In the NutriStack database, Valproic Acid has 7 documented interactions. The most notable include Alcohol, Lamotrigine, Calcium, L-Carnitine, and Methylfolate. Check any specific combination before taking it and confirm with your prescriber.
Does Valproic Acid deplete any nutrients?
Valproic Acid is associated with lowering Carnitine, Folate, Vitamin D, Calcium, and Biotin with prolonged use. Useful biomarkers to monitor include Plasma free carnitine, Serum folate or RBC folate, and 25-OH vitamin D. Ask your prescriber before adding any replacement supplement.
Is it safe to take Alcohol with Valproic Acid?
NutriStack classifies the Alcohol and Valproic Acid pairing as caution: Alcohol can add to valproic acid's dizziness, sleepiness, and impaired coordination, and it may increase concern for liver injury. A case-control study of valproic... Avoid heavy or binge alcohol while taking valproic acid, and avoid alcohol completely if you have liver disease or abnormal liver tests. Do not skip... Always confirm with your prescriber.
Check your whole stack
See how valproic acid fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.