Medication·Interactions & depletion·Reviewed June 9, 2026
Vancomycin interactions.
Vancomycin has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Potassium, and Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Vancomycin at a glance.
A quick, data-grounded summary. The full tables are below.
Vancomycin has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Potassium, and Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with vancomycin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Creatine | Caution | Creatine can raise measured serum creatinine and complicate renal assessment for Vancomycin, which depends on kidney function for dosing or toxicity... |
| Magnesium Glycinate | Caution | Intravenous vancomycin is nephrotoxic, particularly at high troughs or with prolonged courses, and renal impairment alters the clearance and balance... |
| Vitamin C | Caution | High-dose intravenous or oral vitamin C is being studied and used in some critical-care protocols. Because intravenous vancomycin is cleared renally... |
| Probiotics | Timing Sensitive | Vancomycin can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower... |
What vancomycin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Magnesium | Mild | Vancomycin nephrotoxicity, particularly with intravenous use, elevated trough concentrations, or concurrent aminoglycosides, can cause acute kidney... | Magnesium glycinate | Serum magnesium (alongside serum creatinine and vancomycin trough levels) |
| Potassium | Mild | Vancomycin-associated acute kidney injury and renal tubular injury can impair potassium reabsorption and lead to renal potassium loss; this is... | – | Serum potassium (alongside serum creatinine and renal function) |
| Vitamin K | Mild | Oral vancomycin used to treat Clostridioides difficile infection suppresses the colonic bacteria that synthesize menaquinone (vitamin K2), which can... | – | Prothrombin time / INR (particularly in patients on warfarin or with low dietary vitamin K intake) |
The full vancomycin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common vancomycin questions.
Quick answers drawn from the tables above.
What interacts with Vancomycin?
In the NutriStack database, Vancomycin has 4 documented interactions. The most notable include Creatine, Magnesium Glycinate, Vitamin C, and Probiotics. Check any specific combination before taking it and confirm with your prescriber.
Does Vancomycin deplete any nutrients?
Vancomycin is associated with lowering Magnesium, Potassium, and Vitamin K with prolonged use. Useful biomarkers to monitor include Serum magnesium (alongside serum creatinine and vancomycin trough levels), Serum potassium (alongside serum creatinine and renal function), and Prothrombin time / INR (particularly in patients on warfarin or with low dietary vitamin K intake). Ask your prescriber before adding any replacement supplement.
Is it safe to take Creatine with Vancomycin?
NutriStack classifies the Creatine and Vancomycin pairing as caution: Creatine can raise measured serum creatinine and complicate renal assessment for Vancomycin, which depends on kidney function for dosing or toxicity monitoring. Tell the prescriber about creatine use and avoid creatine loading during acute illness, kidney injury, or therapy requiring close renal dosing. Always confirm with your prescriber.
Check your whole stack
See how vancomycin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.