Medication·Interactions & depletion·Reviewed June 9, 2026
Voriconazole interactions.
Voriconazole has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Potassium and Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Voriconazole at a glance.
A quick, data-grounded summary. The full tables are below.
Voriconazole has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Potassium and Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with voriconazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Contraindicated | St. John's Wort can induce drug-metabolizing enzymes and transporters and may lower Voriconazole exposure or undermine therapy. |
| Berberine | Caution | Berberine may inhibit CYP enzymes or P-glycoprotein and could increase voriconazole adverse effects in susceptible patients. |
| Ginkgo Biloba | Caution | Ginkgo biloba has been reported to modestly induce CYP2C19 in some pharmacokinetic studies, and CYP2C19 is a major pathway for voriconazole... |
| Green Tea Extract | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Voriconazole. |
| Milk Thistle | Caution | Milk thistle (silymarin) has been reported to modulate CYP3A4 and CYP2C9 activity in some experimental settings, and these enzymes contribute to... |
What voriconazole can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Potassium | Moderate | Hypokalemia is a recognized adverse effect listed in voriconazole prescribing information and reported in clinical use. It commonly arises in the... | Potassium chloride (only under clinician guidance with monitoring; do not self-supplement potassium) | Serum potassium |
| Magnesium | Mild | Hypomagnesemia is reported during voriconazole therapy, often co-occurring with hypokalemia and frequently driven by concurrent therapies such as... | Magnesium (oral repletion such as magnesium glycinate, or IV magnesium sulfate in the inpatient setting; under clinician guidance) | Serum magnesium |
The full voriconazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common voriconazole questions.
Quick answers drawn from the tables above.
What interacts with Voriconazole?
In the NutriStack database, Voriconazole has 5 documented interactions. The most notable include St. John's Wort, Berberine, Ginkgo Biloba, Green Tea Extract, and Milk Thistle. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Voriconazole?
Voriconazole is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Voriconazole deplete any nutrients?
Voriconazole is associated with lowering Potassium and Magnesium with prolonged use. Useful biomarkers to monitor include Serum potassium and Serum magnesium. Ask your prescriber before adding any replacement supplement.
Is it safe to take St. John's Wort with Voriconazole?
NutriStack classifies the St. John's Wort and Voriconazole pairing as contraindicated: St. John's Wort can induce drug-metabolizing enzymes and transporters and may lower Voriconazole exposure or undermine therapy. Avoid St. John's Wort with Voriconazole. Always confirm with your prescriber.
Check your whole stack
See how voriconazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.