NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Celecoxib

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

The only selective COX-2 inhibitor currently available in the U.S., celecoxib provides anti-inflammatory and analgesic effects with a significantly lower risk of GI ulceration and bleeding compared to nonselective NSAIDs. It is used for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and dysmenorrhea.

Evidence tier
Strong
Indexed sources
10 2016–2025
Interactions
0
Category
Prescription
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

The only selective COX-2 inhibitor currently available in the U.S., celecoxib provides anti-inflammatory and analgesic effects with a significantly lower risk of GI ulceration and bleeding compared to nonselective NSAIDs. NutriStack rates the supporting evidence as strong. Common adult dosing is 100–200 mg once or twice daily (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 10 sources.

What it's good for
  • Pain and inflammation relief in osteoarthritis5,7
  • Treatment of rheumatoid arthritis10,9
  • Reduced GI bleeding risk compared to nonselective NSAIDs
  • Treatment of ankylosing spondylitis
  • Acute pain and dysmenorrhea relief5
What to watch for
  • Dyspepsia
  • Diarrhea
  • Abdominal pain
  • Known hypersensitivity to celecoxib or sulfonamides1,2
  • History of aspirin-sensitive asthma or NSAID-triggered bronchospasm

The bottom line

Evidence rating strong. Most-documented uses: pain and inflammation relief in osteoarthritis, treatment of rheumatoid arthritis, reduced gi bleeding risk compared to nonselective nsaids. 10 sources indexed (2016–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Selectively inhibits cyclooxygenase-2 (COX-2) at therapeutic concentrations, reducing prostaglandin synthesis at sites of inflammation while largely sparing COX-1-dependent prostaglandin production in the gastric mucosa and platelets. This selectivity accounts for the improved GI safety profile, though cardiovascular risk remains a concern.

Class
Nonsteroidal Anti-Inflammatory Drug (COX-2 Selective)
Dosing

Dosing & protocol.

Common range
100–200 mg once or twice daily (as prescribed by your physician)
Recommended form
Capsule

Can be taken with or without food; taking with food may slow absorption but does not affect total bioavailability

Safety

Full safety detail.

Side effects

  • Dyspepsia
  • Diarrhea
  • Abdominal pain
  • Headache
  • Peripheral edema
  • Dizziness
  • Elevated blood pressure
  • Cardiovascular thrombotic events

Contraindications

  • Known hypersensitivity to celecoxib or sulfonamides1,2
  • History of aspirin-sensitive asthma or NSAID-triggered bronchospasm
  • Active GI bleeding
  • Severe hepatic impairment
  • Third trimester of pregnancy
  • Perioperative pain in CABG surgery5
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

7

Reference material

3
FAQ

Common questions.

Quick answers about Celecoxib, drawn from the data on this page.

What is Celecoxib?

The only selective COX-2 inhibitor currently available in the U.S., celecoxib provides anti-inflammatory and analgesic effects with a significantly lower risk of GI ulceration and bleeding compared to nonselective NSAIDs. It is used for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and dysmenorrhea.

What is Celecoxib used for?

Commonly cited benefits of Celecoxib include: Pain and inflammation relief in osteoarthritis; Treatment of rheumatoid arthritis; Reduced GI bleeding risk compared to nonselective NSAIDs; Treatment of ankylosing spondylitis; Acute pain and dysmenorrhea relief. NutriStack rates the overall evidence as strong.

What is a typical dose of Celecoxib?

A typical adult dose of Celecoxib is 100–200 mg once or twice daily (as prescribed by your physician). The commonly recommended form is Capsule. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Celecoxib?

Reported side effects include dyspepsia, diarrhea, abdominal pain, headache, peripheral edema, dizziness. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Celecoxib?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Celecoxib in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.