Dasiglucagon

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Dasiglucagon is an FDA-approved glucagon analog peptide rescue drug available as prescription Zegalogue for severe hypoglycemia in adults and pediatric patients with diabetes aged 6 years and older. This app supports FDA-approved prescription Zegalogue only; compounded, research-use, lyophilized peptide-vial, non-prescribed, or unverified dasiglucagon products are unsupported.

Exploratory record, not a reviewed medical publication.

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This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Dasiglucagon is an FDA-approved glucagon analog peptide rescue drug available as prescription Zegalogue for severe hypoglycemia in adults and pediatric patients with diabetes aged 6 years and older. NutriStack rates the supporting evidence as strong. Common adult dosing is Prescription rescue use only; dose, repeat-dose instructions, age limits, and caregiver training must follow the FDA-approved Zegalogue label., though a prescriber sets the actual dose. This profile indexes 1 source.

What it's good for

Ready-to-use rescue treatment for severe hypoglycemia in diabetes¹
Single-dose autoinjector and prefilled syringe options
Raises blood glucose through glucagon-receptor activation when hepatic glycogen is available
FDA-approved for adults and pediatric patients aged 6 years and older¹

What to watch for

Nausea
Vomiting
Headache
Pheochromocytoma¹
Insulinoma¹

The bottom line

Evidence rating strong. Most-documented uses: ready-to-use rescue treatment for severe hypoglycemia in diabetes, single-dose autoinjector and prefilled syringe options, raises blood glucose through glucagon-receptor activation when hepatic glycogen is available. 1 source indexed (2026), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Dasiglucagon is a glucagon analog that activates hepatic glucagon receptors, increasing glycogenolysis and gluconeogenesis so the liver releases glucose into blood when glycogen stores are adequate.¹

Class

Hypoglycemia Rescue

Dosing

Dosing & protocol.

Common range

Prescription rescue use only; dose, repeat-dose instructions, age limits, and caregiver training must follow the FDA-approved Zegalogue label.

Recommended form

FDA-approved prescription Zegalogue autoinjector or prefilled syringe selected by the diabetes clinician. Do not substitute research peptides, compounded dasiglucagon, unlabeled vials, or non-prescribed products.

Administered by subcutaneous injection using the FDA-approved Zegalogue single-dose autoinjector or prefilled syringe. The solution should be inspected before use and the device should not be reused.

Safety

Full safety detail.

Side effects

Nausea
Vomiting
Headache
Diarrhea
Injection-site pain
Transient blood pressure or pulse changes
Hypersensitivity reactions (rare)

Contraindications

Pheochromocytoma¹
Insulinoma¹

Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Reference material

1ZEGALOGUE (dasiglucagon) injection: prescribing informationSource linkedURLU.S. Food and Drug Administration / DailyMed · Official prescribing information and FDA drug safety communication · 2026
Label covers dasiglucagon rescue for severe hypoglycemia in diabetes age 6 years and older, emergency assistance, oral carbohydrates after response, pheochromocytoma and insulinoma contraindications, decreased-glycogen warning, interactions with beta-blockers/indomethacin/warfarin, and pregnancy risk language.

FAQ

Common questions.

Quick answers about Dasiglucagon, drawn from the data on this page.

What is Dasiglucagon?

What is Dasiglucagon used for?

Commonly cited benefits of Dasiglucagon include: Ready-to-use rescue treatment for severe hypoglycemia in diabetes; Single-dose autoinjector and prefilled syringe options; Raises blood glucose through glucagon-receptor activation when hepatic glycogen is available; FDA-approved for adults and pediatric patients aged 6 years and older. NutriStack rates the overall evidence as strong.

What is a typical dose of Dasiglucagon?

A typical adult dose of Dasiglucagon is Prescription rescue use only; dose, repeat-dose instructions, age limits, and caregiver training must follow the FDA-approved Zegalogue label.. The commonly recommended form is FDA-approved prescription Zegalogue autoinjector or prefilled syringe selected by the diabetes clinician. Do not substitute research peptides, compounded dasiglucagon, unlabeled vials, or non-prescribed products.. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Dasiglucagon?

Reported side effects include nausea, vomiting, headache, diarrhea, injection-site pain, transient blood pressure or pulse changes. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Dasiglucagon?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Dasiglucagon in NutriStack.

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