NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Reviewed May 26, 2026

Dasiglucagon

Prescription ·Strong evidence ·Reviewed May 2026

Dasiglucagon is an FDA-approved glucagon analog peptide rescue drug available as prescription Zegalogue for severe hypoglycemia in adults and pediatric patients with diabetes aged 6 years and older. This app supports FDA-approved prescription Zegalogue only; compounded, research-use, lyophilized peptide-vial, non-prescribed, or unverified dasiglucagon products are unsupported.

Evidence tier
Strong
Indexed sources
1 2026
Interactions
0
Category
Prescription
Read the sources → Compare profiles
What it's good for
  • Ready-to-use rescue treatment for severe hypoglycemia in diabetes1
  • Single-dose autoinjector and prefilled syringe options
  • Raises blood glucose through glucagon-receptor activation when hepatic glycogen is available
  • FDA-approved for adults and pediatric patients aged 6 years and older1
What to watch for
  • Nausea
  • Vomiting
  • Headache
  • Pheochromocytoma1
  • Insulinoma1

The bottom line

Evidence rating strong. Most-documented uses: ready-to-use rescue treatment for severe hypoglycemia in diabetes, single-dose autoinjector and prefilled syringe options, raises blood glucose through glucagon-receptor activation when hepatic glycogen is available. 1 source indexed (2026), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Dasiglucagon is a glucagon analog that activates hepatic glucagon receptors, increasing glycogenolysis and gluconeogenesis so the liver releases glucose into blood when glycogen stores are adequate.1

Class
Hypoglycemia Rescue
Dosing

Dosing & protocol.

Common range
Prescription rescue use only; dose, repeat-dose instructions, age limits, and caregiver training must follow the FDA-approved Zegalogue label.
Recommended form
FDA-approved prescription Zegalogue autoinjector or prefilled syringe selected by the diabetes clinician. Do not substitute research peptides, compounded dasiglucagon, unlabeled vials, or non-prescribed products.

Administered by subcutaneous injection using the FDA-approved Zegalogue single-dose autoinjector or prefilled syringe. The solution should be inspected before use and the device should not be reused.

Safety

Full safety detail.

Side effects

  • Nausea
  • Vomiting
  • Headache
  • Diarrhea
  • Injection-site pain
  • Transient blood pressure or pulse changes
  • Hypersensitivity reactions (rare)

Contraindications

  • Pheochromocytoma1
  • Insulinoma1
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Reference material

1
  • 1ZEGALOGUE (dasiglucagon) injection: prescribing informationSource linkedURLU.S. Food and Drug Administration / DailyMed · Official prescribing information and FDA drug safety communication · 2026

    Label covers dasiglucagon rescue for severe hypoglycemia in diabetes age 6 years and older, emergency assistance, oral carbohydrates after response, pheochromocytoma and insulinoma contraindications, decreased-glycogen warning, interactions with beta-blockers/indomethacin/warfarin, and pregnancy risk language.

Keep exploring

Deep dives & adjacent profiles.

GlucagonPrescriptionSemaglutidePrescriptionPramlintidePrescriptionLiraglutidePrescriptionInsulin LisproPrescriptionInsulin GlarginePrescription

This page is educational. Do not start, stop, or change a supplement or medication based on it without checking with a qualified healthcare professional.

Use this with your stack

Dasiglucagon in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

Download on the App Store → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.