NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Enoxaparin

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Enoxaparin is a low-molecular-weight heparin used for prevention and treatment of deep vein thrombosis and pulmonary embolism, as well as in acute coronary syndromes. It is the most widely used LMWH and has more predictable pharmacokinetics than unfractionated heparin, allowing weight-based dosing with fewer monitoring requirements.

Evidence tier
Strong
Indexed sources
10 2018–2023
Interactions
0
Category
Prescription
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Enoxaparin is a low-molecular-weight heparin used for prevention and treatment of deep vein thrombosis and pulmonary embolism, as well as in acute coronary syndromes. NutriStack rates the supporting evidence as strong. Common adult dosing is Prophylaxis: 30 mg SC q12h or 40 mg SC daily; Treatment: 1 mg/kg SC q12h or 1.5 mg/kg SC daily (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 10 sources.

What it's good for
  • Effective DVT/PE prevention and treatment6,8
  • Predictable dose-response allows weight-based dosing
  • Subcutaneous administration for outpatient use
  • Bridge therapy to warfarin
  • Acute coronary syndrome management10
What to watch for
  • Bleeding
  • Injection site bruising and pain
  • Thrombocytopenia (HIT, rare but serious)
  • Active major bleeding10
  • History of heparin-induced thrombocytopenia (HIT) with enoxaparin

The bottom line

Evidence rating strong. Most-documented uses: effective dvt/pe prevention and treatment, predictable dose-response allows weight-based dosing, subcutaneous administration for outpatient use. 10 sources indexed (2018–2023), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Binds to antithrombin III (AT-III) via a specific pentasaccharide sequence, enhancing AT-III's ability to inactivate factor Xa (primarily) and thrombin (factor IIa) to a lesser extent. The anti-Xa to anti-IIa ratio is approximately 3.8:1, compared to 1:1 for unfractionated heparin. This preferential anti-Xa activity provides effective anticoagulation with a lower bleeding risk profile.

Class
Low-Molecular-Weight Heparin (LMWH)
Dosing

Dosing & protocol.

Common range
Prophylaxis: 30 mg SC q12h or 40 mg SC daily; Treatment: 1 mg/kg SC q12h or 1.5 mg/kg SC daily (as prescribed by your physician)
Recommended form
Subcutaneous injection (prefilled syringes)

Administered subcutaneously only (do not give IM); bioavailability approximately 100% via SC route

Safety

Full safety detail.

Side effects

  • Bleeding
  • Injection site bruising and pain
  • Thrombocytopenia (HIT, rare but serious)
  • Elevated liver transaminases
  • Anemia
  • Osteoporosis (with long-term use)

Contraindications

  • Active major bleeding10
  • History of heparin-induced thrombocytopenia (HIT) with enoxaparin
  • Hypersensitivity to enoxaparin, heparin, or pork products1,2
  • Active peptic ulcer or recent hemorrhagic stroke
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

5

Reference material

5
FAQ

Common questions.

Quick answers about Enoxaparin, drawn from the data on this page.

What is Enoxaparin?

Enoxaparin is a low-molecular-weight heparin used for prevention and treatment of deep vein thrombosis and pulmonary embolism, as well as in acute coronary syndromes. It is the most widely used LMWH and has more predictable pharmacokinetics than unfractionated heparin, allowing weight-based dosing with fewer monitoring requirements.

What is Enoxaparin used for?

Commonly cited benefits of Enoxaparin include: Effective DVT/PE prevention and treatment; Predictable dose-response allows weight-based dosing; Subcutaneous administration for outpatient use; Bridge therapy to warfarin; Acute coronary syndrome management. NutriStack rates the overall evidence as strong.

What is a typical dose of Enoxaparin?

A typical adult dose of Enoxaparin is Prophylaxis: 30 mg SC q12h or 40 mg SC daily; Treatment: 1 mg/kg SC q12h or 1.5 mg/kg SC daily (as prescribed by your physician). The commonly recommended form is Subcutaneous injection (prefilled syringes). These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Enoxaparin?

Reported side effects include bleeding, injection site bruising and pain, thrombocytopenia (hit, rare but serious), elevated liver transaminases, anemia, osteoporosis (with long-term use). This is educational information; check with a healthcare professional before use.

How strong is the evidence for Enoxaparin?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Enoxaparin in NutriStack.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.