Lurasidone

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Lurasidone is an atypical antipsychotic used for schizophrenia and bipolar depression. It must be taken with a meal of at least 350 calories for adequate absorption and is highly dependent on CYP3A4 metabolism. It carries boxed warnings for increased mortality in elderly patients with dementia-related psychosis and suicidal thoughts and behaviors in younger patients when used for bipolar depression.

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In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Lurasidone is an atypical antipsychotic used for schizophrenia and bipolar depression. NutriStack rates the supporting evidence as strong. Common adult dosing is Schizophrenia: commonly 40-160 mg once daily with food. Bipolar depression: commonly 20-120 mg once daily with food., though a prescriber sets the actual dose. This profile indexes 3 sources.

What it's good for

Treatment of schizophrenia in adults and adolescents¹
Treatment of bipolar depression as monotherapy or adjunctive therapy¹
Lower average metabolic burden than some antipsychotics, though monitoring remains necessary

What to watch for

Somnolence
Akathisia
Nausea
Hypersensitivity to lurasidone^1,2
Concomitant strong CYP3A4 inhibitors such as ketoconazole or clarithromycin²

The bottom line

Evidence rating strong. Most-documented uses: treatment of schizophrenia in adults and adolescents, treatment of bipolar depression as monotherapy or adjunctive therapy, lower average metabolic burden than some antipsychotics, though monitoring remains necessary. 3 sources indexed (2011–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Lurasidone antagonizes dopamine D2 and serotonin 5-HT2A receptors and has additional activity at 5-HT7, 5-HT1A, and alpha-2C receptors. Antipsychotic and mood effects are attributed to dopamine-serotonin modulation. It is primarily metabolized by CYP3A4, so strong CYP3A4 inhibitors or inducers can produce unsafe exposure changes and are contraindicated.^1,2

Class

Atypical antipsychotic

Absorption

Water-soluble; take with food

Dosing

Dosing & protocol.

Common range

Schizophrenia: commonly 40-160 mg once daily with food. Bipolar depression: commonly 20-120 mg once daily with food.

Recommended form

Oral tablet taken once daily with at least 350 calories

Must be taken with food containing at least 350 calories; fasting administration markedly lowers exposure and can reduce efficacy.

Safety

Full safety detail.

Side effects

Somnolence
Akathisia
Nausea
Parkinsonism or extrapyramidal symptoms
Restlessness
Insomnia
Hyperprolactinemia
Orthostatic hypotension
Metabolic changes
Neuroleptic malignant syndrome
Tardive dyskinesia

Contraindications

Hypersensitivity to lurasidone^1,2
Concomitant strong CYP3A4 inhibitors such as ketoconazole or clarithromycin²
Concomitant strong CYP3A4 inducers such as rifampin, carbamazepine, phenytoin, or St. John's Wort²

Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Reviews & position papers

1Lurasidone for the treatment of schizophrenia: a review of the efficacy and safety profileCitrome L · Expert Opinion on Pharmacotherapy · 2011
Review summarizes antipsychotic efficacy and common adverse effects including akathisia and somnolence.

Reference material

2LURASIDONE HYDROCHLORIDE tablets, US Prescribing InformationURLU.S. National Library of Medicine · DailyMed · 2025
Labeling documents 350-calorie administration requirement, dosing, CYP3A4 contraindications, and boxed warnings.
3Effect of food on the pharmacokinetics of lurasidonePreskorn SH et al. · Clinical Pharmacology in Drug Development · 2013
Food-effect data support the 350-calorie administration requirement in labeling.

FAQ

Common questions.

Quick answers about Lurasidone, drawn from the data on this page.

What is Lurasidone?

What is Lurasidone used for?

Commonly cited benefits of Lurasidone include: Treatment of schizophrenia in adults and adolescents; Treatment of bipolar depression as monotherapy or adjunctive therapy; Lower average metabolic burden than some antipsychotics, though monitoring remains necessary. NutriStack rates the overall evidence as strong.

What is a typical dose of Lurasidone?

A typical adult dose of Lurasidone is Schizophrenia: commonly 40-160 mg once daily with food. Bipolar depression: commonly 20-120 mg once daily with food.. The commonly recommended form is Oral tablet taken once daily with at least 350 calories. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Lurasidone?

Reported side effects include somnolence, akathisia, nausea, parkinsonism or extrapyramidal symptoms, restlessness, insomnia. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Lurasidone?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

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