Mycophenolate Mofetil
Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Mycophenolate mofetil is an immunosuppressive prodrug of mycophenolic acid used to prevent organ transplant rejection in combination regimens. It carries boxed warnings for embryofetal toxicity, malignancies, and serious infections, and its absorption can be reduced by magnesium/aluminum antacids and some binders.
Exploratory record, not a reviewed medical publication.
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What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Mycophenolate mofetil is an immunosuppressive prodrug of mycophenolic acid used to prevent organ transplant rejection in combination regimens. NutriStack rates the supporting evidence as strong. Common adult dosing is Kidney transplant adults: commonly 1 g orally twice daily. Heart or liver transplant adults: commonly 1.5 g orally twice daily. Dosing varies by transplant protocol, tolerability, cytopenias, infection, and kidney function., though a prescriber sets the actual dose. This profile indexes 3 sources.
The bottom line
Evidence rating strong. Most-documented uses: prevention of kidney transplant rejection, prevention of heart transplant rejection, prevention of liver transplant rejection. 3 sources indexed (1996–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Mycophenolate mofetil is hydrolyzed to mycophenolic acid, a selective, reversible inhibitor of inosine monophosphate dehydrogenase. This blocks de novo guanosine nucleotide synthesis, which T and B lymphocytes rely on heavily for proliferation. Enterohepatic recirculation contributes to exposure, and antacid or binder effects can reduce absorption.1,3
Dosing & protocol.
Often taken on an empty stomach for consistency, but may be taken with food if needed for gastrointestinal tolerability if the transplant team agrees. Separate from magnesium/aluminum antacids and binders that can reduce absorption.
Full safety detail.
Side effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Leukopenia
- Anemia
- Thrombocytopenia
- Serious infections
- Lymphoma and skin cancers
- Pregnancy loss and congenital malformations
- Gastrointestinal bleeding or ulceration
- Progressive multifocal leukoencephalopathy rarely
Contraindications
- Known hypersensitivity to mycophenolate mofetil, mycophenolic acid, or formulation components1,3
- Pregnancy unless no suitable alternatives and benefits outweigh risks under REMS requirements3
- Avoid live vaccines during significant immunosuppression
- Use caution with active serious infection, severe cytopenias, gastrointestinal ulcer disease, or hypoxanthine-guanine phosphoribosyltransferase deficiency3,2
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
1- 1A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantationThe Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group · Transplantation · 1996
Pivotal transplant trials established efficacy for rejection prophylaxis.
Reviews & position papers
1- 2KDIGO Clinical Practice Guideline for the Care of Kidney Transplant RecipientsKidney Disease: Improving Global Outcomes · American Journal of Transplantation · 2009
Guideline supports monitoring blood counts, infections, malignancy prevention, and drug interactions in transplant care.
Reference material
1- 3Mycophenolate Mofetil Tablets US Prescribing InformationURLU.S. National Library of Medicine · DailyMed · 2026
Labeling describes transplant indications, boxed warnings, pregnancy testing and contraception requirements, cytopenias, infections, and absorption interactions.
Common questions.
Quick answers about Mycophenolate Mofetil, drawn from the data on this page.
What is Mycophenolate Mofetil?
Mycophenolate mofetil is an immunosuppressive prodrug of mycophenolic acid used to prevent organ transplant rejection in combination regimens. It carries boxed warnings for embryofetal toxicity, malignancies, and serious infections, and its absorption can be reduced by magnesium/aluminum antacids and some binders.
What is Mycophenolate Mofetil used for?
Commonly cited benefits of Mycophenolate Mofetil include: Prevention of kidney transplant rejection; Prevention of heart transplant rejection; Prevention of liver transplant rejection; Steroid- and calcineurin-inhibitor-sparing component of transplant regimens. NutriStack rates the overall evidence as strong.
What is a typical dose of Mycophenolate Mofetil?
A typical adult dose of Mycophenolate Mofetil is Kidney transplant adults: commonly 1 g orally twice daily. Heart or liver transplant adults: commonly 1.5 g orally twice daily. Dosing varies by transplant protocol, tolerability, cytopenias, infection, and kidney function.. The commonly recommended form is Oral capsule, tablet, suspension, or supervised intravenous formulation; do not crush tablets or open capsules unnecessarily because of teratogenic handling concerns. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Mycophenolate Mofetil?
Reported side effects include diarrhea, nausea, vomiting, abdominal pain, leukopenia, anemia. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Mycophenolate Mofetil?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Mycophenolate Mofetil in NutriStack.
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