NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Risperidone

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Prescription second-generation (atypical) antipsychotic approved for schizophrenia, bipolar mania, and irritability associated with autistic disorder. One of the most widely studied atypical antipsychotics with strong evidence for efficacy. Carries a notable risk of hyperprolactinemia and dose-dependent extrapyramidal symptoms at higher doses. Available as a long-acting injectable. Dosage must be determined by your prescribing physician.

Evidence tier
Strong
Indexed sources
10 1995–2025
Interactions
0
Category
Prescription
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Prescription second-generation (atypical) antipsychotic approved for schizophrenia, bipolar mania, and irritability associated with autistic disorder. NutriStack rates the supporting evidence as strong. Common adult dosing is 1–8 mg daily (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 10 sources.

What it's good for
  • Psychotic symptom reduction
  • Bipolar mania treatment5
  • Irritability reduction in autism9
  • Long-acting injectable option for adherence
  • Well-studied efficacy profile10
What to watch for
  • Hyperprolactinemia (gynecomastia, galactorrhea, amenorrhea)
  • Weight gain
  • Sedation
  • Known hypersensitivity to risperidone or paliperidone1,2
  • Parkinson's disease or Lewy body dementia

The bottom line

Evidence rating strong. Most-documented uses: psychotic symptom reduction, bipolar mania treatment, irritability reduction in autism. 10 sources indexed (1995–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Potently antagonizes dopamine D2 and serotonin 5-HT2A receptors. Also has high affinity for alpha-1 and alpha-2 adrenergic and histamine H1 receptors. The active metabolite 9-hydroxyrisperidone (paliperidone) has similar receptor binding. High D2 affinity at higher doses increases the risk of EPS and prolactin elevation.

Class
Atypical Antipsychotic
Dosing

Dosing & protocol.

Common range
1–8 mg daily (as prescribed by your physician)
Recommended form
Tablet, orally disintegrating tablet, oral solution, or long-acting injectable

Can be taken with or without food. Risperdal Consta (LAI) given IM every 2 weeks requires 3-week overlap with oral supplementation at initiation.

Safety

Full safety detail.

Side effects

  • Hyperprolactinemia (gynecomastia, galactorrhea, amenorrhea)
  • Weight gain
  • Sedation
  • Extrapyramidal symptoms (dose-dependent)
  • Orthostatic hypotension
  • Dizziness
  • Metabolic effects

Contraindications

  • Known hypersensitivity to risperidone or paliperidone1,2
  • Parkinson's disease or Lewy body dementia
  • Concurrent use of drugs that prolong QT interval3,5
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

2

Reviews & position papers

5

Reference material

3
FAQ

Common questions.

Quick answers about Risperidone, drawn from the data on this page.

What is Risperidone?

Prescription second-generation (atypical) antipsychotic approved for schizophrenia, bipolar mania, and irritability associated with autistic disorder. One of the most widely studied atypical antipsychotics with strong evidence for efficacy. Carries a notable risk of hyperprolactinemia and dose-dependent extrapyramidal symptoms at higher doses. Available as a long-acting injectable. Dosage must be determined by your prescribing physician.

What is Risperidone used for?

Commonly cited benefits of Risperidone include: Psychotic symptom reduction; Bipolar mania treatment; Irritability reduction in autism; Long-acting injectable option for adherence; Well-studied efficacy profile. NutriStack rates the overall evidence as strong.

What is a typical dose of Risperidone?

A typical adult dose of Risperidone is 1–8 mg daily (as prescribed by your physician). The commonly recommended form is Tablet, orally disintegrating tablet, oral solution, or long-acting injectable. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Risperidone?

Reported side effects include hyperprolactinemia (gynecomastia, galactorrhea, amenorrhea), weight gain, sedation, extrapyramidal symptoms (dose-dependent), orthostatic hypotension, dizziness. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Risperidone?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Risperidone in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

Download on the App Store → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.