Solifenacin
Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Solifenacin is an antimuscarinic used for overactive bladder with urgency, frequency, and urge urinary incontinence. It improves bladder storage by relaxing detrusor muscle but can cause dry mouth, constipation, urinary retention, heat intolerance, cognitive effects in susceptible patients, and QT prolongation in high-risk settings.
Exploratory record, not a reviewed medical publication.
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This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Solifenacin is an antimuscarinic used for overactive bladder with urgency, frequency, and urge urinary incontinence. NutriStack rates the supporting evidence as strong. Common adult dosing is Adults: 5 mg orally once daily; may increase to 10 mg once daily if tolerated. Do not exceed 5 mg daily in severe renal impairment, moderate hepatic impairment, or with strong CYP3A4 inhibitors; avoid in severe hepatic impairment., though a prescriber sets the actual dose. This profile indexes 3 sources.
The bottom line
Evidence rating strong. Most-documented uses: reduction in urinary urgency, reduction in urinary frequency, reduction in urge urinary incontinence episodes. 3 sources indexed (2004–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Solifenacin competitively antagonizes muscarinic receptors, with functional selectivity for bladder M3 receptor-mediated detrusor contraction. Reduced parasympathetic bladder activity increases bladder capacity and decreases urgency episodes. Systemic anticholinergic effects explain dry mouth, constipation, blurred vision, urinary retention, and possible central effects, while CYP3A4 metabolism creates interaction concerns with inhibitors and inducers.1,3
Dosing & protocol.
May be taken with or without food. Maintain hydration and bowel regimen if constipation occurs.3
Full safety detail.
Side effects
- Dry mouth
- Constipation
- Blurred vision
- Dyspepsia
- Urinary retention
- Somnolence
- Confusion in susceptible patients
- Heat intolerance
- Angioedema rarely
- QT prolongation in high-risk patients
Contraindications
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Randomized controlled trials
1- 1Solifenacin once daily therapy in overactive bladderChapple CR et al. · BJU International · 2004
Randomized data support reductions in urgency, frequency, and incontinence episodes with solifenacin.
Reviews & position papers
1- 2AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive BladderAmerican Urological Association · AUA Guideline · 2024
Guideline recommends shared decision-making for antimuscarinics and beta-3 agonists with attention to retention, constipation, and cognitive risks.
Reference material
1- 3Solifenacin Succinate Tablets US Prescribing InformationURLU.S. National Library of Medicine · DailyMed · 2026
Labeling describes 5 to 10 mg dosing, dose limits, contraindications, anticholinergic adverse effects, and QT warning in high-risk patients.
Common questions.
Quick answers about Solifenacin, drawn from the data on this page.
What is Solifenacin?
Solifenacin is an antimuscarinic used for overactive bladder with urgency, frequency, and urge urinary incontinence. It improves bladder storage by relaxing detrusor muscle but can cause dry mouth, constipation, urinary retention, heat intolerance, cognitive effects in susceptible patients, and QT prolongation in high-risk settings.
What is Solifenacin used for?
Commonly cited benefits of Solifenacin include: Reduction in urinary urgency; Reduction in urinary frequency; Reduction in urge urinary incontinence episodes; Improved bladder storage in overactive bladder. NutriStack rates the overall evidence as strong.
What is a typical dose of Solifenacin?
A typical adult dose of Solifenacin is Adults: 5 mg orally once daily; may increase to 10 mg once daily if tolerated. Do not exceed 5 mg daily in severe renal impairment, moderate hepatic impairment, or with strong CYP3A4 inhibitors; avoid in severe hepatic impairment.. The commonly recommended form is Oral tablet once daily; oral suspension for pediatric neurogenic detrusor overactivity when indicated by product labeling. These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Solifenacin?
Reported side effects include dry mouth, constipation, blurred vision, dyspepsia, urinary retention, somnolence. This is educational information; check with a healthcare professional before use.
How strong is the evidence for Solifenacin?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Solifenacin in NutriStack.
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