NutriStack
Alpha-Lipoic Acid and L-Glutathione, a synergy.
Alpha-lipoic acid raises intracellular glutathione and, with glutathione, participates in a regenerating antioxidant cycle that restores other antioxidants.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and L-Glutathione
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Alpha-lipoic acid raises intracellular glutathione and, with glutathione, participates in a regenerating antioxidant cycle that restores other antioxidants.
Mechanism. Dihydrolipoic acid (the reduced form of alpha-lipoic acid) regenerates reduced glutathione from its oxidized form and supports cysteine uptake, increasing the cellular glutathione pool.
Recommendation. Can be combined to support antioxidant capacity; alpha-lipoic acid helps maintain reduced glutathione levels.
Sources (2)
- Packer L et al, Alpha-lipoic acid as a biological antioxidant, Free Radical Biology and Medicine, 1995
- Han D et al, Lipoic acid increases de novo synthesis of cellular glutathione, BioFactors, 1997
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and L-Glutathione are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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