Supplement × Supplement·Evidence index
PubMed indexes 8 records that name L-Glutathione and Selenium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to L-Glutathione and Selenium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“Tissues particularly sensitive to changes in selenium supply include red blood cells, kidney and muscle. The meta-analysis identified that for animal species selenium-enriched foods were more effective than selenomethionine at increasing GPx activity.”
Names both L-Glutathione and Selenium in its title.
“Saturation of platelet GSH-Px activity occurred at lower plasma Se levels when selenite or selenate were used as Se supplements than with the organic forms. Interpretation of some of the results is provided and ideas are suggested for consideration in further studies.”
Names both L-Glutathione and Selenium in its title.
“These interactions can, however, be modified by increasing the amount of selenium in the feed. Among RA patients there is no clear evidence of an interaction between gold, selenium and GSH-Px.(ABSTRACT TRUNCATED AT 400 WORDS)”
Names both L-Glutathione and Selenium in its title.
“This study reveals that SeD and TMT induce thymic injury by triggering mitochondrial dysfunction and ferroptosis via the miR-7480-5p/SIRT3/GSH axis, providing novel mechanistic insights and potential intervention targets and potential interventions for TMT pollution in selenium-deficient regions.”
Names both L-Glutathione and Selenium in its title.
“Thus, Compd. 5, a synthetic selenium-based small molecule with specific GPX4-like activity, represents a new class of anti-ferroptotic agents with significant translational potential for the treatment of neurodegenerative and other ferroptosis-driven diseases.”
Names both L-Glutathione and Selenium in its title.
“However, the glutathione peroxidase 4 (GPX4) inhibitor RSL3 and knockdown of GPX4, CTH, or xCT via siRNA abolished the protective effect of SS against MT-induced nephrotoxicity, indicating that SS exhibited antiferroptotic effects via the GSH-GPX4 antioxidant system. Overall, MT-induced ferroptosis triggers nephrotoxicity, and SS is a promising therapeutic drug for alleviating MT-induced renal injury by activating the GSH-GPX4 axis.”
Names both L-Glutathione and Selenium in its title.
“Notably, combined supplementation with GSH and Se more effectively increased the GSH/glutathione disulfide ratio and GPx activity than individual supplementation. Supplementation with GSH and Se attenuated liver injury in DEN-induced hepatocarcinogenic mice by enhancing GSH and its related antioxidant capacities, thereby mitigating oxidative damage.”
Names both L-Glutathione and Selenium in its title.
Names both L-Glutathione and Selenium in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers L-Glutathione, Selenium, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
