NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Selenium and Vitamin C: what the published research says

PubMed indexes 3 records that name Selenium and Vitamin C together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Selenium and Vitamin C. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

3 studies naming Selenium and Vitamin C.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine.

Current opinion in chemical biology · 2023 · PMID 37236134

ReviewResearch Support, N.I.H., Extramural

“Thioredoxin reductase can reduce oxidized forms of ergothioneine. While the biological significance of this is not yet realized, this discovery underscores the centrality of selenium to all three antioxidants.”

Hondal · From the abstract

Names both Selenium and Vitamin C in its title.

The antioxidants--vitamin C,vitamin E, selenium, and carotenoids.

Journal of agromedicine · 2003 · PMID 14563626

ReviewHuman subjects

“Although this comprehensive report on the dietary reference intakes for vitamin C, vitamin E, selenium, and the carotenoids did not decisively confirm the role of antioxidants for the prevention of chronic diseases in humans, many research studies have generated new data to support this concept. Additional research is needed to define the attributes of antioxidants as studies progress from in vitro and animal studies to human nutrition.”

Johnson et al. · From the abstract

Names both Selenium and Vitamin C in its title.

Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis.

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014 · PMID 24144963

Meta-AnalysisSystematic ReviewHuman subjects

“The lower plasma nutrient levels indicate that patients with AD have impaired systemic availability of several nutrients. This difference appears to be unrelated to the classic malnourishment that is well known to be common in AD, suggesting that compromised micronutrient status may precede protein and energy malnutrition.”

Lopes da Silva et al. · Authors' conclusion

Names Selenium and Vitamin C together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Selenium, Vitamin C, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.