NutriStack
Coenzyme Q10 Ubiquinol and Selenium, a synergy.
Selenium-dependent enzymes help regenerate ubiquinol after it is oxidized during antioxidant activity, so the two nutrients complement each other in supporting cardiac and antioxidant status.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Coenzyme Q10 Ubiquinol and Selenium
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Selenium-dependent enzymes help regenerate ubiquinol after it is oxidized during antioxidant activity, so the two nutrients complement each other in supporting cardiac and antioxidant status.
Mechanism. Ubiquinol is the reduced antioxidant form of coenzyme Q10. The selenium-dependent enzyme thioredoxin reductase can reduce oxidized ubiquinone back toward ubiquinol, so selenium status influences how effectively this regeneration cycle runs.
Recommendation. Reasonable to combine, especially with marginal selenium intake. A typical pairing is selenium 100 to 200 mcg with ubiquinol 100 to 200 mg daily. No timing separation is needed.
Sources (2)
- Alehagen U et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013;167(5):1860-6. PMID 22626835
- Xia L et al. The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. J Biol Chem. 2003;278(4):2141-6. PMID 12435734
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 Ubiquinol and Selenium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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