NutriStack
Lycopene and Selenium, a synergy.
Lycopene and selenium have complementary antioxidant actions and have been studied together for prostate health and as antioxidant combinations.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Lycopene and selenium have complementary antioxidant actions and have been studied together for prostate health and as antioxidant combinations.
Mechanism. Lycopene is a lipid-phase carotenoid that quenches singlet oxygen and lipid peroxyl radicals, while selenium is incorporated into glutathione peroxidase and thioredoxin reductase enzymes that detoxify peroxides, so the two act on different but complementary arms of the antioxidant defense system.
Recommendation. Reasonable to combine for antioxidant and prostate support. Keep selenium within safe limits (do not exceed about 200 mcg daily) to avoid selenium toxicity.
Sources (2)
- Vance TM, Su J, Fontham ET, Koo SI, Chun OK. Dietary antioxidants and prostate cancer: a review. Nutrition and Cancer, 2013
- Sahin K et al. Comparative evaluation of the antioxidant effects of lycopene and selenium combination. Nutrition Research, 2011
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lycopene and Selenium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.