Lycopene and Saw Palmetto: what the research found
PubMed indexes 8 records that name Lycopene and Saw Palmetto together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.
A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.
Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.
“By triggering multiple inflammatory and oxidative pathways, the combined administration of SrE, selenium and lycopene might likely improve the sperm quality. Proper studies are needed to test this hypothesis. Finally, since prostatitis can affect the sperm quality and considering the anti-estrogenic properties of SrE, we speculate about a possible specific indication in those patients with male infertility and…”
“Patients with mild pre-biopsy LUTS treated with post-biopsy phytotherapeutic combination showed reduced odds of short-term IPSS increase at 1-week after biopsy compared to untreated patients. These results are hypothesis-generating and prospective randomized trials are needed to confirm these findings.”
“We have shown that treatment with SeR-Se-Ly was not inferior to tadalafil 5 mg for improving IPSS and Qmax in men with LUTS.”
The research
8 studies naming Lycopene and Saw Palmetto.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
European review for medical and pharmacological sciences · 2019 · PMID 31002161
Systematic ReviewHuman subjects
“By triggering multiple inflammatory and oxidative pathways, the combined administration of SrE, selenium and lycopene might likely improve the sperm quality. Proper studies are needed to test this hypothesis. Finally, since prostatitis can affect the sperm quality and considering the anti-estrogenic properties of SrE, we speculate about a possible specific indication in those patients with male infertility and "metabolic" prostatitis (where obesity and abnormal…”
Names both Lycopene and Saw Palmetto in its title.
“The combination of serenoa repens, selenium, lycopene + bromelain and methylsulfonylmethane extracts improved the clinical efficacy of levofloxacin in patients affected by CBP without the development of side effects.”
Names both Lycopene and Saw Palmetto in its title.
“Patients with mild pre-biopsy LUTS treated with post-biopsy phytotherapeutic combination showed reduced odds of short-term IPSS increase at 1-week after biopsy compared to untreated patients. These results are hypothesis-generating and prospective randomized trials are needed to confirm these findings.”
Names both Lycopene and Saw Palmetto in its title.
“SeR-Se-Ly could be a valid alternative to dutasteride, providing comparable effects on symptoms related to LUTS/BPH and avoiding sexual dysfunctions. SeR-Se-Ly should not be substituted for dutasteride in those patients for whom prostate volume reduction is desired.”
Names both Lycopene and Saw Palmetto in its title.
Current medicinal chemistry · 2013 · PMID 23432584
ReviewHuman subjects
Names both Lycopene and Saw Palmetto in its title.
Limitations
What this evidence cannot tell you.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.
How to read this page
A literature summary, not guidance.
A study listed here is not proof that Lycopene and Saw Palmetto interact. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen. Our timing guide and forms guide explain the general mechanisms.
Nearby evidence
Other pairs with published research.
Pages covering Lycopene or Saw Palmetto alongside a different substance.
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Lycopene, Saw Palmetto, and several hundred other substances.
Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
