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Supplement × Prescription·Evidence index

Finasteride and Saw Palmetto: what the research found

PubMed indexes 8 records that name Finasteride and Saw Palmetto together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“We also clinically observed, that finasteride acts in both the front area and the vertex, while Serenoa repens prevalently in the vertex. Obviously other studies will be necessary to clarify the mechanisms that cause the different responses of these two treatments.”

Rossi et al. · 2012 · Human study · details

“CP/CPPS treated with saw palmetto had no appreciable long-term improvement. In contrast, patients treated with finasteride had significant and durable improvement in all various parameters except voiding. Further studies are warranted to ascertain the mechanism and reproducibility of these effects in a placebo controlled trial.”

Kaplan et al. · 2004 · Human study · details

“For control versus finasteride-treated men, the tissue androgen values obtained with needle biopsy specimens were similar-both for absolute values and the percentage of change-to those previously reported using surgically excised volumes of prostatic tissue. The quantification of prostatic androgens by assay of needle biopsies is thus feasible and offers the possibility of serial studies in individual patients.”

The research

8 studies naming Finasteride and Saw Palmetto.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.

International journal of immunopathology and pharmacology · 2012 · PMID 23298508

Comparative StudyLetterRandomized Controlled Trial

“We also clinically observed, that finasteride acts in both the front area and the vertex, while Serenoa repens prevalently in the vertex. Obviously other studies will be necessary to clarify the mechanisms that cause the different responses of these two treatments.”

Rossi et al. · From the abstract

Names both Finasteride and Saw Palmetto in its title.

A prospective, 1-year trial using saw palmetto versus finasteride in the treatment of category III prostatitis/chronic pelvic pain syndrome.

The Journal of urology · 2004 · PMID 14665895

Clinical TrialComparative StudyRandomized Controlled Trial

“CP/CPPS treated with saw palmetto had no appreciable long-term improvement. In contrast, patients treated with finasteride had significant and durable improvement in all various parameters except voiding. Further studies are warranted to ascertain the mechanism and reproducibility of these effects in a placebo controlled trial.”

Kaplan et al. · Authors' conclusion

Names both Finasteride and Saw Palmetto in its title.

Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens.

Urology · 2001 · PMID 11337315

Clinical TrialRandomized Controlled Trial

“For control versus finasteride-treated men, the tissue androgen values obtained with needle biopsy specimens were similar-both for absolute values and the percentage of change-to those previously reported using surgically excised volumes of prostatic tissue. The quantification of prostatic androgens by assay of needle biopsies is thus feasible and offers the possibility of serial studies in individual patients.”

Marks et al. · Authors' conclusion

Names both Finasteride and Saw Palmetto in its title.

Pharmacological effects of the lipidosterolic extract of Serenoa repens (Permixon) on rat prostate hyperplasia induced by hyperprolactinemia: comparison with finasteride.

The Prostate · 2000 · PMID 10725865

Comparative StudyAnimal study

“Finasteride was only capable of inhibiting the effect of androgens on rat prostate enlargement. LSESR inhibited not only the androgenic but also the trophic effect of PRL in rat LP hyperplasia.”

Van Coppenolle et al. · Authors' conclusion

Names both Finasteride and Saw Palmetto in its title.

Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers.

European urology · 1994 · PMID 7805711

Clinical TrialComparative StudyRandomized Controlled Trial

“However, the corresponding serum testosterone levels remained within the normal ranges. These data confirm the efficacy of finasteride as inhibitor of 5 alpha-reductase.(ABSTRACT TRUNCATED AT 250 WORDS)”

Strauch et al. · From the abstract

Names both Finasteride and Saw Palmetto in its title.

Comparative Study of the Efficacy and Tolerability of Palmex® (Roystonea regia Lipid Extract), Saw Palmetto, Finasteride and Tamsulosin in Patients with Benign Prostatic Hyperplasia.

Urology research & practice · 2025 · PMID 40248996

“Palmex® for 6 months demonstrated to have a comparable efficacy to saw palmetto, finasteride, and tamsulosin in patients with mild and moderate BPH, being safe and well tolerated.”

Mederos et al. · Authors' conclusion

Names both Finasteride and Saw Palmetto in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Finasteride, Saw Palmetto, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.