NutriStack
Pine Bark Extract and Saw Palmetto, a synergy.
Saw palmetto and pine bark extract (pycnogenol) are sometimes stacked in men's urinary and prostate formulas, pairing hormonal support with anti-inflammatory and circulatory effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Pine Bark Extract and Saw Palmetto
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Saw palmetto and pine bark extract (pycnogenol) are sometimes stacked in men's urinary and prostate formulas, pairing hormonal support with anti-inflammatory and circulatory effects.
Mechanism. Saw palmetto inhibits 5-alpha reductase, while pine bark proanthocyanidins reduce inflammation and support pelvic microcirculation and nitric oxide signaling, addressing different contributors to BPH symptoms.
Recommendation. Reasonable to combine for prostate and lower urinary tract support. Typical doses are saw palmetto 320 mg/day and pine bark extract 100 to 150 mg/day; allow 8 to 12 weeks for symptom change.
Sources (2)
- Ledda A et al, Benign prostatic hypertrophy: Pycnogenol supplementation improves prostate symptoms and lower urinary tract function, Minerva Urologica e Nefrologica, 2018
- Suzuki M et al, Saw palmetto extract suppresses 5-alpha reductase activity, Journal of Ethnopharmacology, 2009
Stack Score
How this pair moves the number.
Effect on the composite score
If both Pine Bark Extract and Saw Palmetto are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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