NutriStack
Pine Bark Extract and Vitamin C, a synergy.
Vitamin C regenerates the oxidized flavonoid components of pine bark extract, helping sustain their antioxidant and endothelial-protective activity.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Pine Bark Extract and Vitamin C
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Vitamin C regenerates the oxidized flavonoid components of pine bark extract, helping sustain their antioxidant and endothelial-protective activity.
Mechanism. Ascorbate reduces flavonoid radicals back to their active form after they neutralize reactive oxygen species, extending the effective antioxidant capacity of the pine bark procyanidins.
Recommendation. Reasonable to take together for antioxidant and vascular support. No separation needed.
Sources (2)
- Packer L et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine bark (Pycnogenol). Free Radical Biology and Medicine, 1999
- Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics, 2002
Stack Score
How this pair moves the number.
Effect on the composite score
If both Pine Bark Extract and Vitamin C are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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