NutriStack
Grape Seed Extract and Pine Bark Extract, a synergy.
Both are oligomeric proanthocyanidin sources with overlapping antioxidant and endothelial nitric-oxide-supporting effects, giving additive vascular antioxidant support.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Grape Seed Extract and Pine Bark Extract
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both are oligomeric proanthocyanidin sources with overlapping antioxidant and endothelial nitric-oxide-supporting effects, giving additive vascular antioxidant support.
Mechanism. Grape seed and pine bark extracts both supply oligomeric proanthocyanidins that scavenge free radicals and enhance endothelial nitric oxide; their mechanisms overlap rather than diverge.
Recommendation. Combining is reasonable but largely redundant given the overlapping mechanism; consider whether one alone meets your goal to avoid unnecessary dosing.
Sources (2)
- Bagchi D et al., Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention, Toxicology, 2000
- Rohdewald P, A review of the French maritime pine bark extract (Pycnogenol), International Journal of Clinical Pharmacology and Therapeutics, 2002
Stack Score
How this pair moves the number.
Effect on the composite score
If both Grape Seed Extract and Pine Bark Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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