NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Grape Seed Extract and Iron: what the published research says

PubMed indexes 7 records that name Grape Seed Extract and Iron together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Grape Seed Extract and Iron. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

7 studies naming Grape Seed Extract and Iron.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.

Complementary therapies in clinical practice · 2023 · PMID 37832335

Randomized Controlled Trial

“GSE supplement possesses several health beneficial influences on children with β-TM by alleviating iron burden, oxidative stress, inflammation, and liver dysfunction.”

Mottaghi et al. · Authors' conclusion

Names both Grape Seed Extract and Iron in its title.

Foliar Co-Applications of Nitrogen and Iron on Vines at Different Developmental Stages Impacts Wine Grape (Vitis vinifera L.) Composition.

Plants (Basel, Switzerland) · 2024 · PMID 39204639

“Further, there was a significant increase in the relative content of amino acids and flavonoids. In conclusion, the application of Fe and N fertilizers at the pre-expansion and late veraison stages of grapes can significantly improve the quality and yield of berries; ultimately, this establishes a foundation for future improvement in the nutritional value of grapes and wine.”

Fu et al. · From the abstract

Names both Grape Seed Extract and Iron in its title.

Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020 · PMID 31570250

Animal study

“GSPAs have protective effects on nephrotoxicity in rats with iron overload. Thus, further investigation of GSPAs as a new and natural phytochemo-preventive agent against iron overload is warranted.”

Yun et al. · Authors' conclusion

Names both Grape Seed Extract and Iron in its title.

Alleviation Effect of Grape Seed Proanthocyanidins on Neuronal Apoptosis in Rats with Iron Overload.

Biological trace element research · 2020 · PMID 31236816

Animal study

“Conversely, the rats exhibited better recovery when GSPCs were used instead of iron alone. In summary, GSPCs protected against iron overload induced neuronal apoptosis in rats by maintaining the divalent mineral element balance, reducing oxidative stress, and regulating apoptotic genes expressions.”

Yun et al. · From the abstract

Names both Grape Seed Extract and Iron in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Grape Seed Extract, Iron, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.