NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Ginkgo Biloba and Grape Seed Extract: what the published research says

PubMed indexes 6 records that name Ginkgo Biloba and Grape Seed Extract together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Ginkgo Biloba and Grape Seed Extract. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Ginkgo Biloba and Grape Seed Extract.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid, Vitis vinifera L. and Ginkgo biloba, Compared to Placebo, Avanafil or a Combination of Nutraceutical Plus Avanafil in Males With Type 2 Diabetes Mellitus With Erectile Dysfunction.

Frontiers in endocrinology · 2022 · PMID 35464055

Clinical Trial

“Blunorm forteĀ® can be helpful and synergic with Avanafil in increasing sexual performance compared to placebo.”

Derosa et al. · Authors' conclusion

Names both Ginkgo Biloba and Grape Seed Extract in its title.

An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents.

Planta medica · 2007 · PMID 17611934

Research Support, N.I.H., ExtramuralHuman subjects

“Goldenseal extracts/constituents (20 microM, particularly hydrastine) and ginsenoside Rh1 stimulated ATPase at about half of the activity of the model substrate, verapamil (20 microM). The data suggest that the clearance of a variety of drugs may be diminished by concomitant use of these herbs via inhibition of P450 enzymes, but less so by Pgp-mediated effects.”

Etheridge et al. · From the abstract

Names both Ginkgo Biloba and Grape Seed Extract in its title.

Total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin E, and tert-butylhydroquinone.

Journal of agricultural and food chemistry · 2004 · PMID 15291494

“Seven phenolics in grape seed and green tea extracts were identified that ranged from 15.38 to 1158.49 and 18.3 to 1087.02 mg/100 g of extract, respectively. Plant extracts such as green tea and grape seed extracts can be used to retard lipid oxidation in a variety of food products.”

Rababah et al. · From the abstract

Names both Ginkgo Biloba and Grape Seed Extract in its title.

A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of hypertensive subjects.

European journal of clinical nutrition · 2016 · PMID 26059745

Randomized Controlled Trial

“Our clinical and in vitro data support the theory that this combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.”

Biesinger et al. · Authors' conclusion

Names Ginkgo Biloba and Grape Seed Extract together in an interaction, co-administration, or pharmacokinetic context.

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B.

Drug metabolism and disposition: the biological fate of chemicals · 2006 · PMID 16415120

Comparative StudyHuman subjects

“Extracts of barley, Job's tears, rutin, rafuma, and passionflower were ineffective. These results suggest that coadministration of some dietary supplements may decrease the absorption of orally administered substrates of OATP-B.”

Fuchikami et al. · From the abstract

Names Ginkgo Biloba and Grape Seed Extract together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Ginkgo Biloba, Grape Seed Extract, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.