From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Both provide vascular polyphenols and may support endothelial function.
Mechanism. Complementary antioxidant and nitric-oxide-supporting mechanisms.
Recommendation. Use moderate doses and monitor for dizziness if blood pressure is low.
Stack Score
How it moves the number.
Effect on the composite score
If both Grape Seed Extract and Pomegranate Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Sumner MD et al. Pomegranate myocardial perfusion. Am J Cardiol. 2005.Needs sourceNo link