NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Grape Seed Extract and Pomegranate Extract: what the published research says

PubMed indexes 8 records that name Grape Seed Extract and Pomegranate Extract together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Grape Seed Extract and Pomegranate Extract. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Grape Seed Extract and Pomegranate Extract.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Comparison of Punica granatum, Terminalia chebula, and Vitis vinifera Seed Extracts used as Mouthrinse on Salivary Streptococcus mutans Levels in Children.

The journal of contemporary dental practice · 2019 · PMID 31797848

Randomized Controlled Trial

“This in vivo study implied that V. vinifera had shown the lowest plaque reduction owing to its antioxidant and phytochemical properties. And P. granatum showed the maximum substantivity.”

Mishra et al. · Authors' conclusion

Names both Grape Seed Extract and Pomegranate Extract in its title.

INFLUENCE OF POMEGRANATE SEED OIL AND GRAPE SEED OIL ON CHOLESTEROL CONTENT AND FATTY ACIDS PROFILE IN LIVERS OF CHICKENS.

Acta poloniae pharmaceutica · 2017 · PMID 29624268

Comparative StudyAnimal study

“It proves that PA is effectively converted into RA in chickens organisms. Pomegranate seed oil seems to be an interesting feed additive in chicken feeding which can improve FA profile of poultry meat.”

Bialek et al. · From the abstract

Names both Grape Seed Extract and Pomegranate Extract in its title.

Variability in the antioxidant activity of dietary supplements from pomegranate, milk thistle, green tea, grape seed, goji, and acai: effects of in vitro digestion.

Journal of agricultural and food chemistry · 2014 · PMID 24745654

Comparative StudyHuman subjects

“The AA after in vitro simulated digestion of the mouth, stomach, and small intestine compared to undigested supplement was decreased for green tea and grape seed but increased for pomegranate, resveratrol, milk thistle, goji, and acai to various extents. Although polyphenols provide the major antioxidant potency of the tested supplements, our observations indicate that digestion may alter antioxidant properties depending in part on the variations in polyphenol content.”

Henning et al. · From the abstract

Names both Grape Seed Extract and Pomegranate Extract in its title.

Enhanced formulation and comprehensive analysis of novel natural ointments with grape seed and pomegranate peel infused in olive oil.

Turkish journal of biology = Turk biyoloji dergisi · 2024 · PMID 40104580

“The EVOO-based ointments enriched with GS and PP extracts exhibited strong antioxidant activity, stability, water resistance, and moisturizing properties. The use of phenolic compounds and natural ingredients like beeswax and olive oil underscores the potential of agricultural byproducts in creating sustainable, ecofriendly cosmetics, with promising applications in skincare and therapy.”

Benguechoua et al. · Authors' conclusion

Names both Grape Seed Extract and Pomegranate Extract in its title.

Utilization of pomegranate and black grape seed by-products in yogurt production: Effects on phenolic compounds and antioxidant activity.

Food science & nutrition · 2023 · PMID 38370056

“In conclusion, the functional properties of grape seed powder and pomegranate seed powder make them suitable natural ingredients for enhancing the antioxidant activity of yogurt. The study highlights the potential of utilizing these by-products to develop yogurt products with added health benefits.”

Çalişkanlar et al. · From the abstract

Names both Grape Seed Extract and Pomegranate Extract in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Grape Seed Extract, Pomegranate Extract, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.