Grape Seed Extract and Pomegranate Extract: what the published research says
PubMed indexes 8 records that name Grape Seed Extract and Pomegranate Extract together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Grape Seed Extract and Pomegranate Extract. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.
The research
8 studies naming Grape Seed Extract and Pomegranate Extract.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
The journal of contemporary dental practice · 2019 · PMID 31797848
Randomized Controlled Trial
“This in vivo study implied that V. vinifera had shown the lowest plaque reduction owing to its antioxidant and phytochemical properties. And P. granatum showed the maximum substantivity.”
Names both Grape Seed Extract and Pomegranate Extract in its title.
Acta poloniae pharmaceutica · 2017 · PMID 29624268
Comparative StudyAnimal study
“It proves that PA is effectively converted into RA in chickens organisms. Pomegranate seed oil seems to be an interesting feed additive in chicken feeding which can improve FA profile of poultry meat.”
Names both Grape Seed Extract and Pomegranate Extract in its title.
Journal of agricultural and food chemistry · 2014 · PMID 24745654
Comparative StudyHuman subjects
“The AA after in vitro simulated digestion of the mouth, stomach, and small intestine compared to undigested supplement was decreased for green tea and grape seed but increased for pomegranate, resveratrol, milk thistle, goji, and acai to various extents. Although polyphenols provide the major antioxidant potency of the tested supplements, our observations indicate that digestion may alter antioxidant properties depending in part on the variations in polyphenol content.”
Names both Grape Seed Extract and Pomegranate Extract in its title.
Turkish journal of biology = Turk biyoloji dergisi · 2024 · PMID 40104580
“The EVOO-based ointments enriched with GS and PP extracts exhibited strong antioxidant activity, stability, water resistance, and moisturizing properties. The use of phenolic compounds and natural ingredients like beeswax and olive oil underscores the potential of agricultural byproducts in creating sustainable, ecofriendly cosmetics, with promising applications in skincare and therapy.”
Names both Grape Seed Extract and Pomegranate Extract in its title.
“In conclusion, the functional properties of grape seed powder and pomegranate seed powder make them suitable natural ingredients for enhancing the antioxidant activity of yogurt. The study highlights the potential of utilizing these by-products to develop yogurt products with added health benefits.”
Names both Grape Seed Extract and Pomegranate Extract in its title.
Journal of food science and technology · 2023 · PMID 37790924
Names both Grape Seed Extract and Pomegranate Extract in its title.
Limitations
What this evidence cannot tell you.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.
Nearby evidence
Other pairs with published research.
Pages covering Grape Seed Extract or Pomegranate Extract alongside a different substance.
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Grape Seed Extract, Pomegranate Extract, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.