NutriStack
Lycopene and Vitamin E, a synergy.
Lycopene and vitamin E are lipid-soluble antioxidants that work together in cell membranes and lipoproteins, with vitamin E helping spare and protect lycopene.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Lycopene and vitamin E are lipid-soluble antioxidants that work together in cell membranes and lipoproteins, with vitamin E helping spare and protect lycopene.
Mechanism. Both lycopene and vitamin E partition into the lipid phase of membranes and lipoproteins, where vitamin E (alpha-tocopherol) scavenges lipid peroxyl radicals and can spare and stabilize lycopene, giving cooperative protection against lipid peroxidation.
Recommendation. Reasonable to combine for antioxidant support. Take both with a fat-containing meal to aid absorption.
Sources (2)
- Fuhrman B, Volkova N, Rosenblat M, Aviram M. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxidants and Redox Signaling, 2000
- Stahl W, Sies H. Antioxidant activity of carotenoids. Molecular Aspects of Medicine, 2003
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lycopene and Vitamin E are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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