NutriStack
Amlodipine and Fish Oil, a synergy.
Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (about 2-3 mmHg systolic at doses of 2-3 g/day) and lower triglycerides, complementing amlodipine's antihypertensive effect. The combination is generally beneficial in patients with hypertension or cardiovascular disease.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amlodipine and Fish Oil
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (about 2-3 mmHg systolic at doses of 2-3 g/day) and lower triglycerides, complementing amlodipine's antihypertensive effect. The combination is generally beneficial in patients with hypertension or cardiovascular disease.
Mechanism. EPA and DHA enhance endothelial nitric oxide production, reduce vascular inflammation, and modulate ion channels in cardiomyocytes. These effects complement amlodipine's L-type calcium channel blockade.
Recommendation. Fish oil at 1-3 g/day combined with amlodipine is appropriate for most patients with cardiovascular risk. Monitor blood pressure when starting, and tell your prescriber if you use high doses (>3 g/day) since the hemodynamic effect can become additive.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and Fish Oil are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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