NutriStack
Antihypertensives and Olive Leaf Extract, a caution.
Olive leaf extract has Captopril-comparable blood pressure lowering effects (500mg BID). Oleuropein is a CYP3A4 mechanism-based inhibitor.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Antihypertensives and Olive Leaf Extract
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Olive leaf extract has Captopril-comparable blood pressure lowering effects (500mg BID). Oleuropein is a CYP3A4 mechanism-based inhibitor.
Mechanism. Additive BP reduction plus CYP3A4 mechanism-based inhibition may increase antihypertensive drug exposure.
Recommendation. Monitor blood pressure closely. May need medication dose adjustment.
Sources (4)
- Olive leaf extract comparable to Captopril PMID 21036583
- Oleuropein CYP3A4 inhibition PMID 11527571
- Haidari F, Mohammad-Shahi M, Jalali MT, Ahmadi-Angali K, Shayesteh F. Phenolic-rich extract of olive leaf with a hypocaloric diet alleviates oxidative stress in obese females: a randomized double-blind placebo controlled trial. Nutr Metab Cardiovasc Dis. 2025. PMID 40685267
- Roshani M, Delfan B, Yarahmadi S, Saki M, Birjandi M. Impact of olive leaf extract on pain management and functional improvement in elderly patients with knee osteoarthritis: A randomized controlled trial. Explore (NY). 2025. PMID 39955806
Stack Score
How this pair moves the number.
Effect on the composite score
If both Antihypertensives and Olive Leaf Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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