Interaction databaseSupplement × SupplementReviewed May 2026

Garlic Extract and Olive Leaf Extract, a caution.

Olive leaf extract and garlic extract both modestly lower blood pressure, so combined use may produce additive hypotensive effects.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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At a glance

Substances
Garlic Extract and Olive Leaf Extract
Pair type
Caution
Evidence (highest tier)
Moderate
Source citations
2 sources
Stack Score effect
−5 to your Stack Score (per scored caution row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Olive leaf extract and garlic extract both modestly lower blood pressure, so combined use may produce additive hypotensive effects.

Mechanism. Both contain vasoactive compounds, oleuropein from olive leaf and allicin-derived sulfur compounds from garlic, that promote vasodilation and nitric oxide signaling, additively reducing blood pressure.

Recommendation. Monitor blood pressure when used together, particularly in those already on antihypertensive therapy, and watch for symptoms of low blood pressure.

Sources (2)
  1. Susalit E et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine. 2011;18(4):251-8. PMID 21036583
  2. Ried K et al. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2008;8:13. PMID 18554422

Stack Score

How this pair moves the number.

Effect on the composite score

If both Garlic Extract and Olive Leaf Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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