What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Lisinopril + Olive Leaf Extract pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Lisinopril and Olive Leaf Extract, a synergy.

Q: Can I take Lisinopril and Olive Leaf Extract together?

Yes. The combination of Lisinopril and Olive Leaf Extract produces a measurable benefit. Olive Leaf Extract lowers blood pressure (about 4-11 mm Hg systolic depending on dose) and was non-inferior to captopril for stage 1 hypertension in one randomized trial. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Olive Leaf Extract lowers blood pressure (about 4-11 mm Hg systolic depending on dose) and was non-inferior to captopril for stage 1 hypertension in one randomized trial. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Lisinopril and Olive Leaf Extract
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Olive Leaf Extract lowers blood pressure (about 4-11 mm Hg systolic depending on dose) and was non-inferior to captopril for stage 1 hypertension in one randomized trial. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.

Mechanism. Oleuropein and related polyphenols in olive leaf inhibit ACE activity, improve endothelial nitric oxide bioavailability, and reduce vascular oxidative stress. These actions complement lisinopril.

Recommendation. Olive Leaf Extract 500-1000 mg/day is a typical research dose. Monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lisinopril and Olive Leaf Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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