NutriStack
Berberine and Olive Leaf Extract, a caution.
Both olive leaf extract and berberine can lower blood glucose and blood pressure, so combining them may produce additive hypoglycemic and hypotensive effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Berberine and Olive Leaf Extract
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both olive leaf extract and berberine can lower blood glucose and blood pressure, so combining them may produce additive hypoglycemic and hypotensive effects.
Mechanism. Olive leaf polyphenols (oleuropein) improve insulin sensitivity and have vasodilatory effects, while berberine activates AMPK and improves glucose uptake, giving overlapping glucose-lowering and pressure-lowering activity.
Recommendation. Monitor blood glucose and blood pressure when combining, especially alongside antidiabetic or antihypertensive medication, and adjust as needed.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Olive Leaf Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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