From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Ashwagandha can cause sedation in some patients and may add to lurasidone's CNS effects.
Mechanism. Additive CNS sedation and dizziness.
Recommendation. Use cautiously and avoid combining with other sedatives unless approved by the prescriber.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Lurasidone are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Lurasidone hydrochloride tablets US Prescribing Information. 2025.Needs sourceNo link