Supplement × Prescription·contraindicated·Strong evidence
St. John's Wort is a strong CYP3A4 inducer and can markedly lower lurasidone exposure.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort is a strong CYP3A4 inducer and can markedly lower lurasidone exposure.
Mechanism. CYP3A4 induction accelerates lurasidone metabolism, risking loss of antipsychotic or mood-stabilizing efficacy.
Recommendation. Do not combine St. John's Wort with lurasidone.
Effect on the composite score
If both Lurasidone and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack