NutriStack
Aspirin Low-Dose and Bromelain, a caution.
Bromelain may have antiplatelet and fibrinolytic effects that could add to low-dose aspirin. Human outcome evidence for the exact combination is limited, but bromelain has laboratory evidence of reduced platelet aggregation and thrombus formation. The combination is most concerning with high-dose bromelain, procedures, ulcer history, or other blood thinners.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Aspirin Low-Dose and Bromelain
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Bromelain may have antiplatelet and fibrinolytic effects that could add to low-dose aspirin. Human outcome evidence for the exact combination is limited, but bromelain has laboratory evidence of reduced platelet aggregation and thrombus formation. The combination is most concerning with high-dose bromelain, procedures, ulcer history, or other blood thinners.
Mechanism. Bromelain proteases can reduce platelet aggregation and thrombus formation in experimental systems. Aspirin irreversibly inhibits platelet COX-1, so bromelain may add to antiplatelet and fibrinolytic bleeding risk.
Recommendation. Avoid high-dose bromelain while taking low-dose aspirin unless your clinician agrees. Tell your surgical or dental team about bromelain and seek care for unusual bruising, nosebleeds, black stools, or vomiting blood.
Sources (2)
- Metzig C, Grabowska E, Eckert K, Rehse K, Maurer HR. Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo. In Vivo. 1999;13(1):7-12. PMID 10218125
- Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-1245. PMID 11577981
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin Low-Dose and Bromelain are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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