Interaction databaseSupplement × SupplementReviewed May 2026

Bromelain and Ginkgo Biloba, a caution.

Bromelain has mild antiplatelet and fibrinolytic activity that can add to ginkgo's platelet-inhibiting effect, modestly increasing bleeding risk.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Bromelain and Ginkgo Biloba
Pair type
Caution
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
−5 to your Stack Score (per scored caution row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Caution · Emerging evidence

Caution

What is happening. Bromelain has mild antiplatelet and fibrinolytic activity that can add to ginkgo's platelet-inhibiting effect, modestly increasing bleeding risk.

Mechanism. Ginkgo inhibits platelet-activating factor and aggregation, while bromelain reduces platelet aggregation and promotes fibrinolysis by influencing plasminogen and fibrinogen, so the antiplatelet effects are additive.

Recommendation. Generally safe at normal doses, but use caution if combining with blood thinners or before surgery. Discontinue both ahead of dental or surgical procedures.

Sources (2)
  1. Pavan R et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. PMID 23304525
  2. Bone KM. Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence? Mol Nutr Food Res. 2008;52(7):764-71. PMID 18214851

Stack Score

How this pair moves the number.

Effect on the composite score

If both Bromelain and Ginkgo Biloba are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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