NutriStack
Bromelain and Nattokinase, a caution.
Both have fibrinolytic and antiplatelet activity; combined use additively raises bleeding risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Bromelain and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both have fibrinolytic and antiplatelet activity; combined use additively raises bleeding risk.
Mechanism. Bromelain reduces fibrinogen and has mild antiplatelet activity; nattokinase has direct fibrinolytic activity via plasmin pathway.
Recommendation. Use together cautiously and only with surgical/bleeding-risk awareness. Avoid before procedures.
Sources (4)
- Sumi H et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43(10):1110-1. PMID 3478223
- Kurosawa Y et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
- Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58(9):1234-45. PMID 11577981
- Pavan R et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. PMID 23304525
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bromelain and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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