NutriStack
Berberine and Garlic Extract, a synergy.
Garlic and berberine both lower LDL cholesterol and triglycerides through different mechanisms, giving additive lipid-lowering when combined.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Berberine and Garlic Extract
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Garlic and berberine both lower LDL cholesterol and triglycerides through different mechanisms, giving additive lipid-lowering when combined.
Mechanism. Berberine upregulates hepatic LDL receptors and activates AMPK, while garlic modestly improves lipid profiles and may inhibit cholesterol synthesis, so their cholesterol-lowering effects operate through complementary pathways.
Recommendation. Reasonable to stack for cardiometabolic and lipid goals. Watch for additive blood pressure and glucose lowering, and monitor if also on lipid, antidiabetic, or antihypertensive medication.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Garlic Extract are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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