From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Berberine may lower glucose while tesamorelin can worsen glucose tolerance, complicating monitoring.
Mechanism. Countervailing metabolic effects on glucose regulation.
Recommendation. Do not use supplements to offset tesamorelin-related dysglycemia without clinician oversight; monitor glucose and A1c.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and Tesamorelin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Egrifta WR Prescribing Information. FDA label. 2025.Needs sourceNo link