What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Calcium Alpha-Ketoglutarate + Vitamin D3 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Strong evidence

Calcium Alpha-Ketoglutarate + Vitamin D3

Q: Can I take Calcium Alpha-Ketoglutarate and Vitamin D3 together?

Yes. The combination of Calcium Alpha-Ketoglutarate and Vitamin D3 produces a measurable benefit. Vitamin D3 increases intestinal calcium absorption, complementing the calcium and bone-supportive aims of Ca-AKG. Adequate vitamin D status helps direct absorbed calcium toward useful physiological roles.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Strong evidence

Vitamin D3 increases intestinal calcium absorption, complementing the calcium and bone-supportive aims of Ca-AKG. Adequate vitamin D status helps direct absorbed calcium toward useful physiological roles.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Calcium Alpha-Ketoglutarate and Vitamin D3

Pair type

Synergy

Evidence

Strong

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyStrong evidence

What is happening. Vitamin D3 increases intestinal calcium absorption, complementing the calcium and bone-supportive aims of Ca-AKG. Adequate vitamin D status helps direct absorbed calcium toward useful physiological roles.

Mechanism. Calcitriol upregulates intestinal calcium-binding proteins and transporters, increasing the fraction of dietary and supplemental calcium absorbed.

Recommendation. Maintain adequate vitamin D status alongside Ca-AKG, but monitor total calcium intake, since enhanced absorption plus high calcium load can raise hypercalcemia risk in susceptible individuals.

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium Alpha-Ketoglutarate and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Christakos S, et al. Vitamin D and intestinal calcium absorption. Mol Cell Endocrinol. 2011.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index