Can I take Calcium Alpha-Ketoglutarate and Iron together?

Yes, if you separate them in time. Calcium Alpha-Ketoglutarate and Iron have a documented timing-sensitive interaction. The calcium delivered by Ca-AKG can inhibit absorption of non-heme iron when taken together, an effect well documented for calcium supplements generally.

What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Calcium Alpha-Ketoglutarate + Iron pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Moderate evidence

Calcium Alpha-Ketoglutarate + Iron

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

The calcium delivered by Ca-AKG can inhibit absorption of non-heme iron when taken together, an effect well documented for calcium supplements generally.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Calcium Alpha-Ketoglutarate and Iron

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. The calcium delivered by Ca-AKG can inhibit absorption of non-heme iron when taken together, an effect well documented for calcium supplements generally.

Mechanism. Calcium competes with iron for shared divalent metal absorption pathways (e.g. DMT1) in the enterocyte, reducing iron uptake when co-ingested.

Recommendation. Separate Ca-AKG from oral iron supplements by at least 2 hours. Take iron on an empty stomach with vitamin C when possible.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

7200

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium Alpha-Ketoglutarate and Iron are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Lonnerdal B. Calcium and iron absorption - mechanisms and public health relevance. Int J Vitam Nutr Res. 2010.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index