What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Calcium Alpha-Ketoglutarate + Vitamin K2 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Emerging evidence

Calcium Alpha-Ketoglutarate + Vitamin K2

Q: Can I take Calcium Alpha-Ketoglutarate and Vitamin K2 together?

Yes. The combination of Calcium Alpha-Ketoglutarate and Vitamin K2 produces a measurable benefit. Vitamin K2 activates osteocalcin and matrix Gla protein, helping incorporate calcium into bone and limit vascular calcium deposition, which complements the calcium content of Ca-AKG in a bone-health context.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Emerging evidence

Vitamin K2 activates osteocalcin and matrix Gla protein, helping incorporate calcium into bone and limit vascular calcium deposition, which complements the calcium content of Ca-AKG in a bone-health context.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Calcium Alpha-Ketoglutarate and Vitamin K2

Pair type

Synergy

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyEmerging evidence

What is happening. Vitamin K2 activates osteocalcin and matrix Gla protein, helping incorporate calcium into bone and limit vascular calcium deposition, which complements the calcium content of Ca-AKG in a bone-health context.

Mechanism. Vitamin K2 is a cofactor for gamma-carboxylation of osteocalcin and matrix Gla protein, supporting calcium deposition in bone and reducing soft-tissue calcification.

Recommendation. Pairing vitamin K2 (and vitamin D) with the calcium from Ca-AKG is reasonable for bone goals. No timing separation needed.

Stack Score

How it moves the number.

Effect on the composite score

If both Calcium Alpha-Ketoglutarate and Vitamin K2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas). 2015.Needs sourceNo link

Check your full routine

One pair was the worked example.

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Open the interaction checker → Browse the research index