NutriStack
Carvedilol and Coenzyme Q10, a synergy.
Beta-blockers may reduce CoQ10 levels. CoQ10 supplementation is particularly relevant for carvedilol patients with heart failure, as CoQ10 supports mitochondrial function in failing myocardium.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Carvedilol and Coenzyme Q10
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 5 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Beta-blockers may reduce CoQ10 levels. CoQ10 supplementation is particularly relevant for carvedilol patients with heart failure, as CoQ10 supports mitochondrial function in failing myocardium.
Mechanism. Beta-blockers may impair CoQ10-dependent mitochondrial enzymes. In heart failure, myocardial CoQ10 is depleted. Supplementation supports electron transport chain function.
Recommendation. Consider CoQ10 100-200mg/day for heart failure patients on carvedilol. The Q-SYMBIO trial showed CoQ10 reduced CV mortality in HF.
Sources (5)
- Mortensen SA et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO). JACC Heart Fail. 2014;2(6):641-649. PMID 25282031
- Tsai IC, Hsu CW, Chang CH et al.. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Frontiers in Pharmacology. 2022. PMID 36091835
- Liu Z, Tian Z, Zhao D et al.. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.. Journal of Clinical Endocrinology and Metabolism. 2022. PMID 36337001
- Hou S, Tian Z, Zhao D et al.. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.. Molecular Nutrition & Food Research. 2023. PMID 37118903
- Sazali S, Badrin S, Norhayati MN et al.. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.. BMJ Open. 2021. PMID 33402403
Stack Score
How this pair moves the number.
Effect on the composite score
If both Carvedilol and Coenzyme Q10 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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