NutriStack
Carvedilol and Fish Oil, a synergy.
Omega-3 fatty acids modestly reduce blood pressure and lower triglycerides, and have separate benefits in heart failure (reducing all-cause mortality in some trials). Combined with carvedilol, the regimen is broadly cardioprotective, with minimal interaction risk at typical doses.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Carvedilol and Fish Oil
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Omega-3 fatty acids modestly reduce blood pressure and lower triglycerides, and have separate benefits in heart failure (reducing all-cause mortality in some trials). Combined with carvedilol, the regimen is broadly cardioprotective, with minimal interaction risk at typical doses.
Mechanism. EPA and DHA enhance endothelial NO production, reduce vascular inflammation, modulate ion channels, and may improve left ventricular function. These effects complement carvedilol's reduction in cardiac workload.
Recommendation. Fish oil 1-3 g/day is appropriate alongside carvedilol for most cardiovascular patients. Monitor blood pressure when starting and tell your prescriber if you take high doses (>3 g/day).
Sources (2)
- Zhang X, Ritonja JA, Zhou N, Chen BE, Li X. Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2022;11(11):e025071. PMID 35647665
- Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation. 1993;88(2):523-33. PMID 8339414
Stack Score
How this pair moves the number.
Effect on the composite score
If both Carvedilol and Fish Oil are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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