NutriStack
Celecoxib and Nattokinase, a caution.
Nattokinase may add fibrinolytic effects to celecoxib-related bleeding risk, especially when celecoxib is used with aspirin or in patients with ulcer history. Celecoxib alone is less platelet-active than nonselective NSAIDs, but it can still contribute to GI injury. Nattokinase has human evidence of coagulation and thrombolysis effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Celecoxib and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Nattokinase may add fibrinolytic effects to celecoxib-related bleeding risk, especially when celecoxib is used with aspirin or in patients with ulcer history. Celecoxib alone is less platelet-active than nonselective NSAIDs, but it can still contribute to GI injury. Nattokinase has human evidence of coagulation and thrombolysis effects.
Mechanism. Nattokinase can potentiate fibrinolysis and alter coagulation profiles. Celecoxib inhibits COX-2 and can still produce GI injury, so clot-destabilizing supplements can become clinically relevant in higher-risk settings.
Recommendation. Avoid nattokinase if you take celecoxib with aspirin or other blood-thinning medicines. Stop nattokinase before procedures unless your clinician has specifically approved continued use.
Sources (2)
- Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
- Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, et al. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013;29(4):221-225. PMID 24396387
Stack Score
How this pair moves the number.
Effect on the composite score
If both Celecoxib and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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