NutriStack
Ciprofloxacin and Magnesium Malate, timing-sensitive.
Magnesium malate, like other magnesium salts, releases Mg2+ in the gut that chelates ciprofloxacin and reduces its absorption. The bioavailability reduction is clinically meaningful and can compromise antibiotic efficacy.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Ciprofloxacin and Magnesium Malate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Magnesium malate, like other magnesium salts, releases Mg2+ in the gut that chelates ciprofloxacin and reduces its absorption. The bioavailability reduction is clinically meaningful and can compromise antibiotic efficacy.
Mechanism. Mg2+ from magnesium malate chelates the 3-carboxyl and 4-oxo groups on the fluoroquinolone core, forming insoluble complexes that block enterocyte uptake.
Recommendation. Take ciprofloxacin at least 2 hours before or 6 hours after magnesium malate. Do not co-administer.
Minimum separation. 360
Sources (2)
- Eljaaly K, Helal A, Almandeel T, Algarni R, Alshehri S. Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study. Saudi J Biol Sci. 2021;28(12):6929-6932. PMID 34866992
- Wiesner A, Zagrodzki P, Gawalska A, Paśko P. Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses. Clin Pharmacokinet. 2024;63(6):773-818. PMID 38807006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ciprofloxacin and Magnesium Malate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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