What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Coenzyme Q10 + Nebivolol pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Moderate evidence

Coenzyme Q10 + Nebivolol

Q: Can I take Coenzyme Q10 and Nebivolol together?

Possibly, but with caution. Coenzyme Q10 and Nebivolol have a documented caution-tier interaction. Beta-blockers, including nebivolol, can inhibit CoQ10-dependent enzymes and may lower endogenous CoQ10 levels (a recognized class effect, best characterized with propranolol). Supplemental CoQ10 is generally well tolerated alongside nebivolol, but because CoQ10 may modestly lower blood pressure on its own, the combination can produce additive blood-pressure reduction in some patients.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Moderate evidence

Beta-blockers, including nebivolol, can inhibit CoQ10-dependent enzymes and may lower endogenous CoQ10 levels (a recognized class effect, best characterized with propranolol). Supplemental CoQ10 is generally well tolerated alongside nebivolol, but because CoQ10 may modestly lower blood pressure on its own, the combination can produce additive blood-pressure reduction in some patients.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Coenzyme Q10 and Nebivolol

Pair type

Caution

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionModerate evidence

What is happening. Beta-blockers, including nebivolol, can inhibit CoQ10-dependent enzymes and may lower endogenous CoQ10 levels (a recognized class effect, best characterized with propranolol). Supplemental CoQ10 is generally well tolerated alongside nebivolol, but because CoQ10 may modestly lower blood pressure on its own, the combination can produce additive blood-pressure reduction in some patients.

Mechanism. Beta-blockers inhibit CoQ10-dependent mitochondrial enzymes and may reduce circulating CoQ10. CoQ10 itself can have a mild antihypertensive effect via improved endothelial function and reduced oxidative stress, which can add to nebivolol's blood-pressure-lowering action.

Recommendation. Co-administration is reasonable and may help offset beta-blocker-related CoQ10 depletion, but monitor blood pressure and heart rate, especially when starting CoQ10 or adjusting the nebivolol dose. Report dizziness, lightheadedness, or unusual fatigue to the prescriber.

Stack Score

How it moves the number.

Effect on the composite score

If both Coenzyme Q10 and Nebivolol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977.Needs sourceNo link
2Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007.Needs sourceNo link

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